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B&B Part III > Neuropharm of Alcohol > Flashcards

Neuropharm of Alcohol Flashcards

1
Q

Alcohol takes about ___ minutes to absorb, and most of it is done in the ____ __

A

30; small intestine

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2
Q

Habitual drinkers absorb alcohol faster/slower than occasional drinkers

A

faster

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3
Q

Alcohol is distributed in the ___ ___ ____ but not any specific tissue, and is absorbed in fat so ___ have a higher BAL per drink

A

total body water; women

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4
Q

__% of alcohol is excreted, and __% is metabolized by oxidative pathways

A

10; 90

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5
Q

ADH is mainly present in the ___ and __ (sex) have more of it in the stomach

A

liver; men

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6
Q

The CYP with the highest specificity for alcohol and is induced upon alcohol ingestion is

A

2E1

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7
Q

The ___ pathway also converts Alcohol > Acetaldehyde like ADH but does so when ADH is saturated

A

MEOS

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8
Q

__ enzyme converts acetaldehyde to acetate, h2o and co2

A

ALDH

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9
Q

Alcohol metabolism goes from __ to __ order kinetics after ADH is saturated

A

first; zero

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10
Q

Habitual drinkers have more ____ enzyme and therefore can tolerate alcohol better

A

CYP 2E1

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11
Q

Alcohol competitively inhibits ___ so old people gotta be careful

A

warfarin

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12
Q

Chronic alcoholism causes p450 metabolism of ___ and the breakdown products are extremely toxic

A

acetaminophen

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13
Q

Brain metabolism ___ with chronic alcohol use

A

decreases

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14
Q

CV effects of alcohol acutely include _____ (heart) and ____ (vessels)

A

arrhythmias; vasodilation

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15
Q

Chronic CV effects of alcohol include increased __ levels, increased ___, and cardiac ____

A

triglyceride, blood pressure, myopathy

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16
Q

Three cardioprotective effect of alcohol include increased ____ cholesterol, increased ___ levels, and the drinks themselves provide ___-

A

HDL; TPA; antioxidants

17
Q

Alcohol raises/lowers the pH of the stomach because it increases gastrin and histamine secretion

A

lowers

18
Q

Alcohol is a diuretic because it decreases ___ secretion, and in your piss you specifically lose a lot of ____

A

ADH; potassium

19
Q

You sleep poorly when drunk because inconsistent __ levels

A

co2

20
Q

Alcohol ___ bone marrow products and you’re more prone to ___

A

reduces; infection

21
Q

Chronically alcohol can cause ___ (endocrine effect) and acutely it causes blood sugar levels to ___

A

gynecomastia; fall

22
Q

Sexually, chronic alcohol users get ____ syndrome and their balls ___

A

feminization; shrink

23
Q

Why is alcohol dangerous to the developing fetus?

A

It has no enzymatic machinery to process alcohol

B&B Part III (38 decks)

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