Serotonin Agonists & Antagonists

Question 1

NT found in enterchromaffin cells in gut lumen

Answer 1

serotonin

Question 2

5HT1 agonists
Gi action
present in CNS

Answer 2

Sumatriptan

buspirone

Question 3

5HT1d agonist

used in acute migraine attacks (DOC)

Answer 3

Sumatriptan

Question 4

5HT1a agonist

antianxiety

Answer 4

buspirone

Question 5

present in CNS
Gq action
increase GI secretion, CNS causes excitation and hallucinations

Answer 5

5HT2 Antagonists

Question 6

5HT2 antagonists

antihypertensive

Answer 6

ketanserine

Question 7

5HT2 antagonists

used in schizophrenia

Answer 7

olanzapine

Question 8

5HT2 antagonists

used in carcinoid tumors, increase appetite in children

Answer 8

cyproheptadine

Question 9

5HT2 antagonists

used to prevent migraines, treat severe diarrhea in carcinoid syndrome

Answer 9

methysergide

Question 10

5HT3 antagonists
receptor in CZT, area postrema, peripheral and enteric nerves
control vomiting with chemo patients

Answer 10

ondansetron
granisetron
dolasetron
aldosterone (treats IBS)

Question 11

5HT4 agonist
partial agonist
IBS, pro kinetic
Gs action

Answer 11

tegaserod

Question 12

5HT4 agonist
anti emetic
prokinetic

Answer 12

metocloprimide