Anti Hypertensive Flashcards by bailey craig

Decrease SANS

Decrease HR, TPR, CO

A2 Agonists - Clonidine & Methyldopa

How well did you know this?

Not at all

Perfectly

Tx: opiate, smoking & ethanol withdrawal

Mild & moderate HTN

Clonidine

How well did you know this?

Not at all

Perfectly

Tx: mild & moderate HTN; HTN in pregnancy

Methyldope

How well did you know this?

Not at all

Perfectly

SE: Depression, dry mouth

Sudden withdrawal = hypertensive crisis

Clonidine

How well did you know this?

Not at all

Perfectly

SE: + Coombs test hemolytic anemia

Methyldopa

How well did you know this?

Not at all

Perfectly

Inhibits VMAT - Deceasing NE release
Decreases SANS, HR, BP
Crosses BBB

Reserpine

How well did you know this?

Not at all

Perfectly

SE: Depression, diarrhea, Increase gastric acid secretion

Contraindications: peptic ulcer & depression

Reserpine

How well did you know this?

Not at all

Perfectly

Inhibits re uptake of NE by blocking NET
Decreases SANS, HR, BP
Doesn’t cross BBB

Guanethidine

How well did you know this?

Not at all

Perfectly

SE: Orthostatic HTN, diarrhea, edema, sexual dysfucntion

Contraindications: can be inhibited by NET blockers - cocaine & TCAs

Guanethidine

How well did you know this?

Not at all

Perfectly

Decrease TPR & vasodilate

Alpha Blockers

How well did you know this?

Not at all

Perfectly

Blocks irreversibly A1 & A2

Tx: Secondary HTN

phenooxybenzamine - nonselective

How well did you know this?

Not at all

Perfectly

Blocks reversibly A1 & A2

phentolamine - nonselective

How well did you know this?

Not at all

Perfectly

Blocks A1 reversibly

selective - prazosin, terazosin, tamsulosin, doxazosin

How well did you know this?

Not at all

Perfectly

Tx: HTN emergency by IV

Non selective - phenooxybenzamine & phentolamine

How well did you know this?

Not at all

Perfectly

Tx: Essential HTN

Prazosin & Terazosin

How well did you know this?

Not at all

Perfectly

Tx: BPH

Tamsulosin

ADR: 
1st dose effect
Nasal Blockade
Reflex tachycardia
retroejaculation

Alpha Blockers

Drug of choice to tx - HTN emergency

Labetolol - Alpha & Beta Blocker

Tx: HTN & reduces mortality in patients w/ heart failure

Carvedilol - Alpha & Beta Blocker

Decrease s - CO, TPR, contractility, HR, relaxation rate, conduction velocity
Inhibits renin release

Beta Blockers

Non Selective Beta Blockers

Carteolol
Carvedilol
Labetolol
Nadolol
Penbutolol
Pindolol
Propanolol
Timolol

Selective Beta Blockers

Bisoprolol
Betaxolol
esmolol
Acebutolol
Metaprolol
Atenolol
Nebivolol

Tx: HTN, Angina, MI, Arrhythmias, Heart Failure

Beta Blockers

ADR:
Impaired exercise tolerance
Hyperlipidemia
Diabetes (alter hyperglycemia &amp; mask hypoglycemia)
asthma
heart block/heart failure
sexual dysfunction

Beta Blockers

nervousness, tachycardia, angina, HTN & heart infection

Sudden withdrawal from Beta Blockers

Antidote for over dose of Beta blockers causing heart block/ heart failure

glucagon

``` BP >/= 180/110 without end organ damage severe headache SOB nosebleeds sever anxiety ```

Hypertensive urgency

``` BP >/= 180/120 with damage to at least one organ (brain, heart, kidney) stroke heart attack loss of kidney fucntion loss of consciousness & memory loss damage to eye aortic dissection angina pulmonary edema eclampsia ```

Hypertensive emergency

Hypertensive tx for blacks

Thiazide & CCB

stage 1 HTN tx

mono therapy

stage 2 HTN tx

combo therapy - 2 agents with different MOA

patient has diabetes or kidney disease with HTN what id the treatment

ACE-I, ARBs

blood pressure goal

less than 130/80 mmHg

used to tx HTN in pregnancy

Labetolol Nifedipine methyldopa