Nitric Oxide & PD 5 Inhibitors Flashcards
powerful vasodilator - all smooth muscle are relaxed
promotes inflammation
nitric oxide
used to treat: pulmonary artery hypertension, acute respiratory distress in neonates, slow process of atherosclerosis with arginine supplement
nitric oxide
MOA increased cGMP levels by inhibiting its breakdown by PDE5
nitric oxide
NOS inhibitors
NG mono methyl L arginine
used to treat erectile dysfunction and pulmonary HTN
potentiates action of nitrates
lasts 4-6 hours
sildenafil
moa increases cGMP by inhibiting breakdown of PDE5
sildenfil
ADR: sever hypotension from excess cGMP and MI if taken along with nitrates, blue green color discrimination problems
sildenfil
PDE5 inhibitors
sildenfil
taladafil
vardenafil