Other GI drugs Flashcards
1) Increase absorption and decrease secretion by action on intestinal neurons
2) increase absorption through CNS action
3) increase circular sphincter contraction but decrease propulsive contraction
4) cross BBB
Anti diarrheal drugs: morphine and codeine
1) 1st line treatment for most children with acute gastroenteritis
2) Na and Cl absorption is linked to glucose uptake by enterocyte - followed by passive absorption of water
Oral rehydration therapy
Ulcer not continuous
Has granuloma
Crohns dz
Lesions are continuous
Ulcerative colitis
1st choice treatment for ulcerative colitis
5-ASA
Active form
SE: slow acetylation of sulfapyridine: GI, BM depression, folate absorption decrease
Mesalamine
Treatments for variceal hemorrhage
Octreotide
Vasopressin
Beta blockers
Somatostatin analog Suppresses GI 5HT secretion Reduces GI motility Reduces secretion of fluids by the intestine and pancreas Vasoconstriction Decreases portal vessel pressure
Octreotide
Neutralizing agents for protons of the gut lumen
NaHCO3
CaCO3
Al(OH)3
Mg(OH)2
ADR: systemic alkalosis, fluid retention
NaHCO3
ADR: Hypercalcemia, Nephrolithiasis
CaCO3
ADR: Constipation, hypophosphatemia
Al(OH)3
ADR: diarrhea
Mg(OH)2
Opioids - antidiarrheal
Can not cross BBB
Diphenoxylate - short duration = 4-6 hrs
Loperamide - long duration = 12 hrs
ADR: constipation is most common; paralytic ileus in children
Diphenoxylate
Loperamide
