Laxatives Flashcards
Secretory/ stimulant laxatives
Castor oil
Microlax enema
Bisacodyl
Senna
Target mucosa crypt cells
Increase PG, cAMP, GI secretion
Increase intestine motility by direct stimulation of enteric n
Secretory/ stimulant laxatives
Non absorbable salt osmotic laxatives
Mg hydroxide
Na sulfate
Na phosphate
Mg citrate
Non absorbable sugar osmotic laxatives
Sorbitol
Lactulose
Draw water into the intestinal lumen
SE: electrolyte imbalance and cramps
Effect PGE-3350
Osmotic laxatives
Emollient stool softener laxatives
Docusate
Mineral oil
Glycerin suppository
Lub lower bowel
ADR: decrease absorption of fat soluble vitamins (ADEK)
Emollient stool softener laxatives
Bulk forming agents laxatives
Psyllium, bran, methyl cellulose
Absorb water to form a bulky emollient gel in the distal colon promote peristalsis
Most safe in elderly
Bulk forming laxatives