Prostaglandins

Question 1

PGE inhibitor

used to treat PDA to close it

Answer 1

indomethacin

Question 2

PGE1 analog
used to keep PDA open till surgery
also used in erectile dysfunction inducing vasodilation

Answer 2

alprostadil

Question 3

PGE1 derivative
used to treat NSAID induced peptic ulcer: cox 1 inhibited - decrease PGE - less mucus secretion - gastric mucosal damage by acid - peptic ulcer
used in with mifepristone to induce abortion (morning after pill)

Answer 3

misoprostol

Question 4

PGE2

used to induce labor and abortion

Answer 4

dinoprostone

Question 5

PGF2a

used to induce labor and abortion

Answer 5

carboprost

Question 6

PGF2a
increase AQ humor outflow from anterior chamber
decreases IOP
used to treat glaucoma
SE: dark pigment in iris

Answer 6

latanoprost

Question 7

PGI2
platelet stabilizer and vasodilator
used to treat pulmonary HTN

Answer 7

epoprostenol