Sedative-Hypnotic Drugs

Question 1

Major Inhibitory Neurotransmitters

Answer 1

GABA (CNS)

Glycine (Spinal cord)

Question 2

Major Excitatory Neurotransmitters

Answer 2

Glumate

Aspartate

Question 3

Glycine antagonist

Answer 3

Strycline

Question 4

GABA receptor effects

Answer 4

FREnzodiazepines: FREquency
BarbiDURATes: DURAtion

Question 5

Benzodiazepine Toxicity

Answer 5

Anterograde Amnesia

Question 6

CI in Intermittent Porphyria

Answer 6

Barbiturates

Question 7

Benzodiazepines

Answer 7

Midazolam (short acting)
Lorazepam (Intermediate acting)
Diazepam (Long-acting)

Question 8

What abnormal sleep pattern results from use of benzodiazepines?

Answer 8

decrease REM sleep

Question 9

DOC for Status epilecticus

Answer 9

Diazepam

Question 10

Benzodiazepine w/ the longest halflife

Answer 10

Chlordiazepoxide

Question 11

Date rape drugs

Answer 11

Alcohol (most common)
Flunitrazepam (rohypnol)
Gamma-hydroxybutyrate

Question 12

Antidote for Benzodiazepine overdose

Answer 12

Flumazenil - BZ antagonist

Question 13

Barbiturates

Answer 13

Thiopental (ultrashort acting)
Pentobarbital (short-intermediate acting)
Phentobarbital (long-acting)

Question 14

DOC for children w/ insomia, seizure disorders, status epilepticus
Gilberts syndrome

Answer 14

Phenobarbital

Question 15

Enzyme deficient in Acute Intermittent porphyria

Answer 15

HMD synthase

Question 16

DOC for patients w/ Insomnia ONLY

Answer 16

Zolpidem -selective binding to GABA A receptors

Lack anti-convulsant, anti-anxiety, and muscle relaxant

Question 17

Use in General Anxiety Disorder

MOA- Partial agonist at 5HT1A receptor and possibly D2 receptors

Answer 17

Buspirone