General Anesthetics Flashcards
Highest MAC and lowest partition coefficient among inhaled anesthetics. Lowest Potency. Rapid onset and recovery
Nitrous oxide
Lowest MAC and highest partition coefficient among inhaled anesthetics. Highest Potency. Slow onset and recovery
Methoxyflurane
Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: megaloblastic anemia; euphoria (laughing gas)
Nitrous oxide
Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: Bronchospasms (pulmonary irritant)
Pungent smelling
Desflurane
Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: Renal insufficiency (compound A)
Sweet smelling
Sevoflurane
Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: Coronary steal syndrome
Isoflurane
Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: Spike-and wave activity, muscle twitching, breath-holding
Enflurane
Class: General Anesthetic
MOA: Facilitate GABA A mediated inhibition; block NMDA and ACh-N receptors
SE: Post operative Hepatitis
Malignant Hyperthermia
Halothane
Tx. for Malignant hyperthermia: Dantrolene
Class: General Anesthetic (IV)
MOA: Blocks excitation by glutamate at NMDA receptors
Uses: Dissociative anesthesia (analgesia, amnesia, & catatonia w/ retained consciousness)
SE: Emergence Delirium
Ketamine
Class: General Anesthetic (IV)
MOA: Modulates GABAa receptors containing B3 subunits
Use: General anesthesia (px w/ limited cardiac or respiratory reserve)
Etomidate
Class: General Anesthetic (IV)
MOA: interact w/ opiod receptors
SE: Respiratory depression
Antidote is ?
Fentanyl
Antidote: Naloxone
Neuroleptanesthesia - fentanyl + droperidol + nitrous oxide
Milk anesthesia
Propofol
Potentiates GABA-A receptor; Blocks Na channels
