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Pharmacology 1 > Antiseizure Drugs > Flashcards

Antiseizure Drugs Flashcards

1
Q

MOA- blocks voltage gated Na channels
Uses Grand Mal seizures, partial seizures, arrhythmias (Group 1B)
SE: Gingival hyperplasia, Hirsutism, Fetal hydantoin syndrome

A

Phenytoin

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2
Q

Fetal hydantoin syndrome

A

Upturned nose, mild midfacial hypoplasia, long upper lip w/ thin vermilion border, lower distal digital hypoplasia

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3
Q

Class Tricyclic anticonvulsants
Uses: Grand mal seizures, partial seizures,
Trigeminal neuralgia (DOC)

A

Carbamazepine

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4
Q

Class Anticonvulsant (branch-chain fatty acid)
MOA: blocks high frequency firing of neurons modifies amino acid metabolism
Uses: Grand mal seizures,
Bipolar disorders (acute mania) DOC
Juvenile myoclonic epilepsy DOC
SE: Neural tube defects, spina bifida

A

Valproic Acid

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5
Q

Preferred antiseizure drug in children and pregnant women

A

Phenobarbital

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6
Q 
Class Anticonvulsant (cyclic ureide)
MOA: Decrease Ca2+ (T-type) in thalamus
Use: DOC absence seizure (petit mal)
A

Ethosuximide

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7
Q

DOC of status epilepticus

A

Diazepam
Lorazepam
Phenytoin
Phenobarbital

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8
Q

Anticonvulsant drug w/c is also used for neuropathic pain (postherpetic neuralgia) DOC

A

Gabapentin (GABA derivative)

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9
Q

Anticonvulsant that causes SJS

A

Lamotrigine

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10
Q

Anticonvulsant w/ the most number of mechanism of action

A

Topiramate (monosaccharide derivative)

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11
Q

DOC of Generalized Tonic-clonic seizures

A

Valproic acid
Phenytoin
Carbamazepine

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12
Q

DOC partial seizures

A

Carbamazepine
Lamotrigine
Phenytoin

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13
Q

DOC for Absence Seizures

A

Ethosuximide

Valproic acid

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14
Q

DOC for Myoclonic and atypical absence syndromes

A

Valproic acid

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15
Q

DOC for Bipolar affective disorders

A

Valproic acid (1st line of mania)
Carbamazipine
Lamotrigine

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16
Q

DOC for Trigeminal neuralgia

A

Carbamazipine

17
Q

DOC for Neuropathic pain (Post herpetic neuralgia)

A

Gabapentin

18
Q

DOC for Migraine

A

Gabapentin

Pharmacology 1 (17 decks)

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