Antiviral Chemotherapy & Prophylaxis

Question 0

DOC: CMV
SE: leukopenia

Answer 0

Gancyclovir

Question 1

Antiviral MOA: activated by viral thymidine kinase to form that inhibit viral DNA polymerase

Use: HSV-1, HSV 2, VZV

Answer 1

Acyclovir

Question 2

Antiviral Use: CMV retinitis, molluscom contagiosum (umbilicated papule)

Answer 2

Cifodovir

Question 3

Antiviral MOA- inhibits viral RNA polymerase, DNA polymerase & HIV reverse transcriptase, bind to pyrophosphate binding site
Use: CMV retinitis, HSV infection w/ AIDS
Active against strains of HSV w/ absent thymidine kinase activity

Answer 3

Foscarnet

Question 4

Class: nucleoside reverse transcriptase inhibitor
MOA: inhibit HIV reverse transcriptase after phosphorylation by cellular enzymes
Use: HIV, prevention of maternal fetal HIV transmission

Answer 4

Zidovudine

Abacavir, didanosine, lamivudine, stavudine

Question 5

Zidovudine SE

Answer 5

Lactic acidosis, bone marrow supression

Question 6

Abacavir SE:

Answer 6

Hypersensitivity

Question 7

Didanosine SE:

Answer 7

Pancreatitis

Question 8

Stavudine, Zalcitabine SE:

Answer 8

Peripheral neuropathy

Question 9

Class: non-nucleoside reverse transcriptase inhibitor
MOA: inhibit HIV Reverse transcriptase No phosphorylation required

Answer 9

Delavirdine, eravirenz, etravirine, nevirapine

Question 10

Delavirdine, neviraline SE:

Answer 10

Rash, increased AST/ALT

Question 11

Efavirenz SE:

Answer 11

Teratogenicity

Question 12

Etravirine SE:

Answer 12

Increased cholesterol, triglycerides

Question 13

Nonnucleoside reverse transcriptase inhibitor (NNRTI)

Answer 13

Never Ever Deliver Nucleosides
Nevirapine
Efavirenz
Delavirdine

Question 14

Class: Protease inhibitor
MOA: inhibit viral protein processing
Use: HIV infection
SE: hyperlipidemia, fat redistribution, hyperglycemia, insulin resistance

Answer 14

Indinavir

Question 15

Saquinavir SE

Answer 15

GI distress & diarrhea

Question 16

Atazanavir SE:

Answer 16

Peripheral neuropathy

Question 17

Amprenavir SE

Answer 17

Rash

Question 18

Indinavir SE

Answer 18

Hyperbilirubinemia & nephrolithiasis

Question 19

Class: fusion inhibitor
MOA: binds to gp41 subunit of viral envelope glycoprotein, preventing fusion of viral and cellular membranes

Answer 19

Enfuvirtide

Question 20

Class: CCR5 receptor antagonist

Answer 20

Maraviroc

Question 21

Class: anti-influenza
MOA: inhibit early step replication and prevent uncoating by binding to M2 proton channels
Use: influenza A only, rubella

Answer 21

Amantidine

Question 22

Amantadine SE:

Answer 22

Livido reticularis

Cerebellar dysfunction

Question 23

Class: anti-influenza
MOA: inhibits neuraminidase. Decrease release of progeny virus
Use: influenza A and B, shortens duration of symptoms

DOC for influenza ( includ H1N1)

Answer 23

Oseltamivir

Question 24

Oseltamivir SE:

Answer 24

GI effects

Question 25

Zanamivir SE:

Answer 25

Bronchospasms

Question 26

Class: interferon
MOA: degrades viral RNA via activation of host cell RNAase
Use: HBV, HBC, Kaposi

Answer 26

Interferon alpha

Question 27

MOA: inhibits guanosine triphosphate formation. Prevents capping of viral mRNA. Blocks RNA-dependent RNA polymerase
Use: HCV, RSV

Answer 27

Ribavirin