schizophrenia

Question 1

what does the term schizophrenia mean

Answer 1

splitting of psychic functions

Question 2

what are positive symptoms of schizophrenia

Answer 2

EXCESS of normal functioning

eg. feelings of being controlled

Question 3

what are the negative symptoms of schizophrenia

Answer 3

LOSS of normal functioning

Question 4

define alogia

Answer 4

loss of speech

Question 5

define anhedonia

Answer 5

inability to seek pleasure

Question 6

what percentage of pop is affected by schizophrenia

Answer 6

1%

Question 7

define catatonia

Answer 7

motionless/ lost of movement

Question 8

define avoilition

Answer 8

absence of motivation

Question 9

what are the CR for schizophrenia

Answer 9

mz - 45%

dz - 10%

Question 10

what effect does cocaine have on dopamine and schizophrenia

Answer 10

trigger schizophrenia and increase levels of dopamine

Question 11

what did freud say delusions are a result of

Answer 11

homosexual urges

Question 12

what did chloropromazine used to be used for

Answer 12

antihistamine

Question 13

what effect does chloropromazine have on schizophrenia

Answer 13

calming agent

Question 14

how does chloropromazine work

Answer 14

block dopamine receptor
stop dopamine working
increase affinity

Question 15

where does resperine come from

Answer 15

snake root plant

Question 16

what type of neurotransmission occurs in chloropromazine and resperine

Answer 16

antagonist neurotransmission

Question 17

what side effects does resperine cause

Answer 17

reduction in blood pressure

Question 18

how does resperine work?

Answer 18

reduction in vesicles and reduce dopamine released

Question 19

what similarities occur between chloropromazine and resperine

Answer 19

1. drugs act under same mechanism

2. PD symptoms begin to emerge

Question 20

what are neuroleptics

Answer 20

anti schizophrenia drugd

Question 21

what are atypical neuroleptics

Answer 21

treat schizophrenia without binding strongly to D2 receptors

Question 22

what effects do psychedilic drugs cause

Answer 22

alter perception, cog and emotion

Question 23

what does ketamine mimic

Answer 23

mimic negative effects of schizophrenia

Question 24

what does LSD mimic

Answer 24

mimic the positive symptoms of schizophrenia

Question 25

what do schizophrenia related genes disturb

Answer 25

myelination, glutamate transmissin and GABA synapses

Question 26

what effect does schizophrenia have on the brain

Answer 26

smaller brain size
neuron loss
abnormalities in brain structure

Question 27

what is green IBZM used for

Answer 27

chemical to measure dopamine receptors

Question 28

what is the cause of schizophrenia

Answer 28

hyperactivity specifically at D2 receptors

Question 29

what is the effect of more ‘greenies’ (measure of dopamine receptors

Answer 29

improvement of positive symptoms of S in treatment process

Question 30

what is the effect of good binding process to D2 receptors

Answer 30

more effective to suppress symptoms fo schizophrenia

Question 31

what is the effect of a good binding process to dopamine receptors

Answer 31

increase efficacy of the drug

Question 32

which receptors to chloropromazine and phentothiazines bind to

Answer 32

both D1 AND D2 receptors

Question 33

which receptors do haloperidol and butyrophenoes bind to

Answer 33

bind effectively to D2

dont bind effectively do D1

Question 34

what is D1 coupled with

Answer 34

D1 is positively coupled with adenlyate cylise

Question 35

what is adenlyate cylise

Answer 35

enzyme helps pass message inside the cell

Question 36

what is D2 coupled with

Answer 36

negatively coupled with adenlyate cylise

Question 37

what does clozapine bind effectively to

Answer 37

D4 receptor

Question 38

how many types of dopamine receptor are there

Answer 38

research shows there is more than 1 dopamine receptor