Schizophrenia Flashcards
1
Q
Increased ____ and ____ likely cause of Schizophrenia
A
D2 receptors
5-HT blood concentrations
2
Q
Typical Antipsychotics block…..
A
D2 receptors
3
Q
Atypical Antipsychotics block……
A
5-HT receptors
4
Q
Typical Antipsychotics Examples
A
Haloperidol (-dol)
Chlorpromazine (-zine)
5
Q
Atypical Antipsychotics Examples
A
aripiprazole
clozapine (-pine)
Risperidone
Ziprasidone
6
Q
Clozapine
A
blocks 5-HT and D4
7
Q
Aripiprazole
A
blocks 5-HT
partial agonist of D2
8
Q
SE of D2 Blockers
A
increase prolactin levels- amenorrhea and galactorrhea in women, gynecomastia in men
higher prevalence of diabetes
Extrapyramidal System Dysfunction (EPS)
9
Q
CNS SE of Antipsychotic Drugs
A
EPS akisthisia pseudo-parkinson Tardive dyskinesia Neuroleptic Malignant Syndrome (NMS)
10
Q
SE of Clozapine
A
agranulocytosis
requires weekly WBC counts
11
Q
Drugs for first break schizo
A
Risperidone
Aripiprazole
Ziprasidone
