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Pharmacology II > GI > Flashcards

GI Flashcards

1
Q

Zollinger-Ellison Syndrome

A

gastrinoma that increases gastric acid secretion

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2
Q

H2 Receptor Antagonists Use

A

for peptic ulcers and GERD

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3
Q

Examples of H2 Receptor Antagonists

A

Cimetidine and Ranitidine

Tidines

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4
Q

MoA of H2 Receptor Antagonists

A

blocks histamine on H2 receptors

inhibits gastric acid secretion

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5
Q

PK of Cimetidine

A

P450 inhibitor- lots of drug interactions

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6
Q

SE of Cimetidine

A

drug interactions

antiandogenic effects- gynecomastia

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7
Q

Use of Proton Pump Inhibitors

A

ulcers, esp NSAID induced
GERD
Zollinger Ellison

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8
Q

Examples of Proton Pump Inhibitors

A

Omeprazole

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9
Q

MoA of Proton Pump Inhibitors

A

irreversibly blocks proton pump

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10
Q

Adverse Effects of Proton Pump Inhibitors

A

do not use with clopidogrel- anti-platelet

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11
Q

Eradicating H. Pylori

A

PPI + 2 antibiotics (metronidazole, clarithromycin, amoxicillin, tetracycline)

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12
Q

Types of Antacids

A

aluminum and magnesium hydroxides
calcium carbonates
sodium carbonates

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13
Q

Use of Antacids

A

promote healing of gastric ulcers

relieve symptoms of GERD

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14
Q

SE of Antacids

A

aluminum hydroxides- constipation

magnesium hydroxide- diarrhea

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15
Q

Antacid Interactions

A

2 hr rule for taking other drugs

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16
Q

Sucralfate

A

protects mucosa

needs acidic environment to be activated

17
Q

Bismuth SE

A

black tongue and stools

18
Q

5-ASA drugs used for ulcerative colitis

A

Mesalamine

Sulfasalazine

19
Q

Anti-TNF-a Drugs

example and use

A

infliximab

severe ulcerative colitis

20
Q

Anti-Integrin Drugs

example and use

A

natalizumab

severe ulcerative colitis

21
Q

MoA of Anti-Integrin Drugs

A

blocks leukocyte migration to site of inflammation

22
Q

5HT3 Receptor Blockers

example and use

A

ondansetron

emesis

23
Q

D2 Receptor Blockers

example and use

A

promethazine

emesis

24
Q

1st Gen H1 Blockers

example and use

A

diphenhydramine
emesis
blocks M receptors

25
Q

NK1 Antagonist

example and use

A

aprepitant

emesis

Pharmacology II (16 decks)

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