GI Flashcards
Zollinger-Ellison Syndrome
gastrinoma that increases gastric acid secretion
H2 Receptor Antagonists Use
for peptic ulcers and GERD
Examples of H2 Receptor Antagonists
Cimetidine and Ranitidine
Tidines
MoA of H2 Receptor Antagonists
blocks histamine on H2 receptors
inhibits gastric acid secretion
PK of Cimetidine
P450 inhibitor- lots of drug interactions
SE of Cimetidine
drug interactions
antiandogenic effects- gynecomastia
Use of Proton Pump Inhibitors
ulcers, esp NSAID induced
GERD
Zollinger Ellison
Examples of Proton Pump Inhibitors
Omeprazole
MoA of Proton Pump Inhibitors
irreversibly blocks proton pump
Adverse Effects of Proton Pump Inhibitors
do not use with clopidogrel- anti-platelet
Eradicating H. Pylori
PPI + 2 antibiotics (metronidazole, clarithromycin, amoxicillin, tetracycline)
Types of Antacids
aluminum and magnesium hydroxides
calcium carbonates
sodium carbonates
Use of Antacids
promote healing of gastric ulcers
relieve symptoms of GERD
SE of Antacids
aluminum hydroxides- constipation
magnesium hydroxide- diarrhea
Antacid Interactions
2 hr rule for taking other drugs
Sucralfate
protects mucosa
needs acidic environment to be activated
Bismuth SE
black tongue and stools
5-ASA drugs used for ulcerative colitis
Mesalamine
Sulfasalazine
Anti-TNF-a Drugs
example and use
infliximab
severe ulcerative colitis
Anti-Integrin Drugs
example and use
natalizumab
severe ulcerative colitis
MoA of Anti-Integrin Drugs
blocks leukocyte migration to site of inflammation
5HT3 Receptor Blockers
example and use
ondansetron
emesis
D2 Receptor Blockers
example and use
promethazine
emesis
1st Gen H1 Blockers
example and use
diphenhydramine
emesis
blocks M receptors
NK1 Antagonist
example and use
aprepitant
emesis
