Sarcoidosis Flashcards
1
Q
What type hypersensitivity reaction is involved in sarcoidosis?
A
Type IV Hypersensitivity Reaction
- Delayed type
2
Q
Explain the presentation of sarcoidosis
A
- presence of granulomas
3
Q
Explain the immune response in sarcoidosis
A
Inhalation of unknown antigen
Stimulates alveolar macrophages, CD4+ and CD8+ t cells
failure to clear antigen
granuloma formation
presistent immune activation leads to tissue damage and fibrosis
4
Q
Where are granulomas seen on CXR?
A
- Bilateral hilar Lymphoadenopathy
5
Q
Management of sarcoidosis
A
- spontenous remission
- NSAID (nonsteriod anti-inflammatory drugs)
- systemic corticosteroids
6
Q
Presentation of sarcoidosis
A
- young adults
- eye skin lessions
- bilater hilar lymphadenopathy
7
Q
Investigations
A
- CXR
