Lung cancer Flashcards

1
Q

What does paraneoplastic mean?

A
  • non-metastatic systemic side effects of a malignant tumour

- finger clubbing, weight loss, tiredness etc.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the main causes of a bronchial carcinoma?

A
  • smoking (90%)
  • radon exposure
  • asbestos
  • genetics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Types of lung cancers?

A
  • small cell
  • non-small cell:
  • adenocarcinoma
  • squamous cell carcinoma
  • large cell carcinoma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Symptoms of lung cancer?

A
  • cough (more than 3 weeks)
  • haemoptysis
  • unexplained weightloss
  • breathlessness
  • hoarse voice (recurrent laryngeal nerve)
  • stridor (inspiraton)
  • recurrent pneumonia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Regions of metastic spread?

A
  • brain
  • liver
  • skin
  • adrenal glands
  • bone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Symptoms of liver metasis

A
  • nausea

- anorexia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

symptoms of brain metasis

A
  • headaches

- confusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pancoast tumour?

A
  • apex of lungs

- muscle wasting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

SVC tumour

A
  • superior vena cava
  • reduced drainage from the head and neck
  • swelling in face
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Oesphageal tumour

A
  • dysphagia (difficulty swallowing)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Pain associated with lung cancer?

A
  • invading chest wall

- sharp localised pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pleural effusion?

A
  • Fluid in the pleural space
  • compresses lung
  • breathlessness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What drug can you give for swelling in the brain?

A

Dexamethasone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What causes hypercalcaemia?

A
  • tumour produces hormones that mimic the parathyroid hormone
  • tends to be squamous cell carcinomas
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Treatment of hypercalcaemia?

A
  • Rehydration

- IV bisphosphonate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Treatment of SIADH

A
  • Fluid restrictions <1.5l

- Demeclocycline

17
Q

Investigations into lung cancer?

A
  • CXR
  • CT
  • PET
  • bronchoscopy
18
Q

Why is it important to investigate type of lung cancer?

A
  • appropriate treatment
19
Q

Lung cancer staging?

A

TNM

  • T = Tumour size
  • N = Nodal spread?
  • M = Metasis
20
Q

Treatment of small cell carcinoma

A
  • Chemotherapy (pallitative)

- Pallitative radiotherapy

21
Q

Treatment of non-small cell carcinomas

A
  • depending on metasis
  • non-metasis - surgery, radiotherapy
  • pallitative radiotherapy
  • pallitative care?
22
Q

What is the most common lung cancer in smokers?

A
  • squamous cell carcinoma
23
Q

k-ras and EGFR mutations associated with?

A
  • non-small cell
24
Q

Associated with liver metasis?

A
  • ALP

- Alkaline Phosphatase

25
Q

Prevelance of lung cancer?

A
  • LOW
26
Q

Incidence of lung cancer?

A
  • HIGH
27
Q

TTF-1 associated with what cancers?

A
  • adenocarcioma

- small cell

28
Q

p63 associated with what?

A
  • squamous cell