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CLS 306 > Rh Blood Group > Flashcards

Rh Blood Group Flashcards

1
Q

what is the second most important blood group

A

Rh blood group

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2
Q

does the Rh blood group have naturally occurring AB

A

no

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3
Q

what kind of inheritance does the Rh blood group have

A

mendelian

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4
Q

what kind of chromosomes is the RH gene on

A

haplotype

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5
Q

T or F: the D ag is not immunogenic

A

F

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6
Q

presence of D ag is considered RH ___

A

pos

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7
Q

what chromosome are RHD and RHCE gene

A

chromosome 1

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8
Q

what does RHD code for

A

presence/ absence of the D protein

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9
Q

what does RHCE code for

A

presence of other proteins

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10
Q

what chromosome is the RHAG gene located on

A

chromosome 6

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11
Q

what gene must be present for successful expression of the Rh ag

A

RHAG

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12
Q

what is the order of Rh ag that stimulate the strongest Ag response

A

D> c> E> C> e

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13
Q

which Rh blood group system three separate closely linked genes that produce the ag

A

fisher-race

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14
Q

which Rh blood group system? multiple alleles at one complex locus

A

wiener

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15
Q

what kind of system does rosenfield use

A

numerical

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16
Q

which Rh blood group system adapts well to computer entry

A

rosenfield

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17
Q

what number is D ag (rosenfield)

A

1

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18
Q

what number is C ag (rosenfield)

A

2

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19
Q

what number is E ag (rosenfield)

A

3

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20
Q

what number is c ag (rosenfield)

A

4

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21
Q

what number is e ag (rosenfield)

A

5

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22
Q

what Rh blood group system is used to talk to doctors

A

wiener

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23
Q

what Rh blood group is on ISBT labels

A

rosenfield

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24
Q

def? 6 digit number for each ag specificity

A

ISBT

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25
Q

what do the first 3 digits of the ISBT number indicate

A

blood group system

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26
Q

what do the last 3 digits of the ISBT number indicate

A

ag specificity

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27
Q

what are the 2 functions of the Rh ag

A

mmb integrity and intracellular cation transport

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28
Q

if someone has membrane abnormalities or RBC shortened survival what kind of Rh ag

A

Rh null

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29
Q

what race has the most Rh pos population

A

asians

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30
Q

what causes deleted phenotypes

A

replacement of large portions of RHCE gene with RHD gene

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31
Q

if the RBC lack C/c and or E/e what is the result

A

enhanced D activity

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32
Q

Rh mod =

A

weakened expression of Rh ags

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33
Q

Rh null=

A

no Rh ags expressed

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34
Q

what gene is mutated to have Rh mod

A

RHAG

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35
Q

what kind of Rh null type has a mutated RHAG gene

A

regulator type

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36
Q

what kind of Rh null type has a mutated RHCE gene and deleted RHD gene

A

amorphic type

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37
Q

what kind of Rh blood group has mild hemolytic anemia and reticulocytes

A

Rh null

38
Q

what kind of blood can Rh null pt be transfused with

A

Rh null blood

39
Q

what category of weak D has a reduced amount of D ags

A

quantitative

40
Q

what category of weak D has C inherited in the trans location

A

position effect

41
Q

what category of weak D has a missing part

A

Mosaic

42
Q

if c and D are in double doses what does it cause C to do

A

decreases the expression of D

43
Q

what is put into the tube for forward ABO typing

A

1 drop of regent antisera + 1 drop of pt cells

44
Q

what is put into the tube for reverse ABO typing

A

1 drop of pt serum + 1 drop of red cell reagent

45
Q

is Rh typing forward or reverse typing

A

foward

46
Q

what occurs as a result of not added reagent or serum

A

false neg

47
Q

what rh ag typing reagent has limited availability; expensive; and lengthy incubation time

A

saline reactive

48
Q

can you use saline reactive reagent with a weak D

A

no

49
Q

what rh ag typing reagent increase the likelihood of false pos

A

high protein

50
Q

what has to be run with a high protein rh reagent

A

manufacturer’s control

51
Q

can you use high protein rh reagent with a weak D

A

yes

52
Q

what rh ag typing reagent relaxes ab molecule by breaking disulfide bonds. ab span distance between RBC in low protein medium

A

chemically modified

53
Q

can chemically modified rh reagent be used with weak d

A

yes

54
Q

what rh ag typing reagent hybridize to increase ab production and ab strength

A

monoclonal

55
Q

what is the most common Rh ag typing reagent used

A

monoclonal

56
Q

if a pt is weak D pos what are they considered

A

Rh pos

57
Q

can you give weak d blood to a d neg pt

A

no

58
Q

what do expecting mothers need to be tested for

A

weak d

59
Q

if a mother is Rh neg what do they need to be tested for

A

weak d

60
Q

t or f: some hospitals may or may not test transfusion recipients for weak d

A

t

61
Q

what is done during a du test

A

incubate tubes at 37 C for 15 mins–> spin –> read

62
Q

what is done during a Coomb’s test

A

wash tubes with saline 3x –> add Coomb’s reagent –> spin –> read

63
Q

what happens if the Rh control is pos during a du test

A

test is invalid

64
Q

are IgG clinically. significant

A

yes

65
Q

what temp do Rh ab react at

A

body temp

66
Q

do Rh ab bind C’

A

no

67
Q

The Rh system genes are:

A

RHD and RHCE

68
Q

What Rh antigen is found in 85% of the Caucasian population and is always significant for transfusion purposes?

A

Big D

69
Q

How are weaker-than-expected reactions with anti-D typing reagents categorized?

A

weak D

70
Q

Cells carrying a weak D antigen require the use of what test to demonstrate its presence?

A

Indirect antiglobulin test

71
Q

How are Rh antigens inherited?

A

codominate alleles

72
Q

Biochemically speaking, what type of molecules are Rh antigens?

A

proteins

73
Q

Rh antibodies react best at what temperature (°C)?

A

37

74
Q

Rh antibodies are primarily of which immunoglobulin class?

A

IgG

75
Q

Rh antibodies have been associated with which clinical condition?

A

Hemolytic disease of the fetus and newborn

76
Q

What do Rh null cells lack?

A

Rh ags

77
Q

what is the fisher-race nomenclature from the Weiner nomenclature: R1r

A

DCe/ce

78
Q

what is the fisher-race nomenclature from the Weiner nomenclature: R2R0

A

DcE/Dce

79
Q

what is the fisher-race nomenclature from the Weiner nomenclature: RzR1

A

DCE/DCe

80
Q

what is the fisher-race nomenclature from the Weiner nomenclature: r’r

A

Ce/ce

81
Q

what is the rosenfield nomenclature from the Weiner nomenclature: R1r

A

RH: 1, 2, -3, 4, 5

82
Q

what is the rosenfield nomenclature from the Weiner nomenclature: R2R0

A

RH: 1, -2, 3, 4, 5

83
Q

what is the rosenfield nomenclature from the Weiner nomenclature: RzR1

A

RH: 1, 2, 3, -4, 5

84
Q

what is the rosenfield nomenclature from the Weiner nomenclature: r’r

A

RH: -1, 2, -3, 4, 5

85
Q

what ag are present: R1r

A

D, C, c, e

86
Q

what ag are present: R2R0

A

D, E, c, e

87
Q

what ag are present: RzR1

A

D, C, E, e

88
Q

what ag are present: r’r

A

C, c, e

89
Q

Which Rh phenotype has the strongest expression of D?

A

D-

90
Q

An individual has the following serologic reactions: D+C+E+c+e+f–. What is the most probable genotype?

A

R1R2

91
Q

Which of the following is the most common haplotype in the African American population?

A

Dce

92
Q

If a patient who is R 1 R 1 is transfused with RBCs that are R o r , which antibody is he most likely to produce?

A

anti- c

CLS 306 (19 decks)

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