OTHER BLOOD GROUPS Flashcards
what chromosome are the lewis genes on
19
what 3 sets of alleles control lewis ags
Lele, Sese, Hh
what is produced if there is a Le gene inherited
Lea
what lewis alleles do not produce products
le, h, and se
what is produced if there is an Se gene
Leb
what lewis phenotype are nonsecrators
Le(a+b-)
if someone is sese can they still have Lea present in body fluids
yes
what kind of lewis ags are found in secretions
glycoproteins
what kind of lewis ags are found in plasma
glycolipids
what kind of lewis ag do RBCs adsorb
glycolipids
what gene produces fucosyltrnasferase
FUT3
what lewis phenotype cannot express the Leb phenotype
hh
what is the Bombay phenotype
hh
what do pregnant women have as a lewis phenotype
Le(a-b-)
what lewis phenotype do children have
Le(a+b+)
when can the correct lewis phenotype be obtained
2-3 years
what causes the loss of lewis ag expression on RBCs
abnormal lipid metabolism
what lewis phenotype produces the most abs
Le(a-b-)
what kind of immunoglobulin are lewis abs
IgM
what neutralizes lewis abs
lewis + plasma
what is the more common lewis abs
anti-Lea
what kind of anti-Leb ab reacts when both Leb and H ags are present
anti-LebH
what kind of anti-Leb ab reacts with Leb regardless of the ABO type
anti-LebL
when does the lewis ab agglutinate
IS test phase
can lewis abs bind C’
yes
if a pt’s lewis ab demonstrate hemolytic properties what kind of blood is given to them
Le ag neg blood
what chromosome is the P1 ag on
22
what chromosome is the GLOBE gene on
3
what gene produces the P ag
GLOBE
what chromosome is the Pk ag on
22
what P group ag is more common
P1
what is the null P phenotype
p
what ags are expressed for P1k phenotype
P1 and pk
what abs are produced from P1k phenotype
anti-P
what ags are expressed for P2k phenotype
pk
if the P1 ag is stored for a long time what happens to the ag strength
decreases
where is anti-p1 found
serum of P2 people
what kind of immunoglobin is anti-P1
IgM
what temp is best for anti-P1
low
what neutralizes anti-P1
hydrated cyst fluid
who has anti-P
P1k phenotype
what kind of immunoglobin are anti-P
IgG
what temp is best for anti-P
body temp and room
what kind of p group antibodies do paroxysmal cold hemoglobinuria pt have
auto anti-P
does auto anti-P bind C’
yes
who has anti-Pk
p individuals
what inhibits anti-Pk
hydatid cyst fluid
who has anti-P-P1-Pk
p individuals
what kind of immunoglobulin is anti-P-P1-Pk
IgM
does anti-P-P1-Pk bind C’
yes
what temp does anti-P-P1-Pk agglutinate
room temp
what ab do people with encwinococcus granulosis tapeworm and bird handlers developed
anti-P1
what kind of chain do I ags have
branched
what kind of chain do i ags have
straight
what I group ag do newborns have
i
what I group ag do adults have
I
I adult ag on cell = i ___ ag on cell
cord
what is the term for someone with less amount I adult ag on cells
I intermediate
is anti-I clinically significant
yes
what kind of immunoglobin is anti- I
IgM
what temp does anti- I react
RT
what ab do pts with mycoplasma pneumoniae develop
cold auto anti-I
what I group ab reacts with cord cells
anti-It
what kind of infections are associated with anti-i ab
IM and Epstein-barr virus
what kind of immunoglobin are MN
IgM
what kind of immunoglobin are Ss and U
IgG
what chromosome has genes that code for MNS
4
what do GYPA and GYPB code for
glycophorin A and B
what does GYP code for
M and N
what does GPB code for
S and s
does MNS ags show dosage
yes
what destroys M and N
proteolytic enzymes
where is U ag found
glycophorin B
what other ag is always present when S and s are inherited
U
T or F: U neg cells are very rare
T
what MNS phenotype has partial or complete deletion of GPA
Ena
what MNS phenotype has near-complete deletion of GYPA and GYPB
Mk
does anti-M and anti-N bind C’
no
where are kell ags located
on glycoprotein that is in RBC mmb
what chromosome are kell ag located on
7
what makes kell ags sensitive to treatment with sulfhydryl agents
they have a highly folded disulfide bonded region
K=
kell
k=
cellano
what ag is expressed with this phenotype: Ko/Knull
Kx
what chromosome is Kx gene located on
X chromosome
what kind of immunoglobin are kell abs
IgG
what chromosome is the Duffy blood group
1
what Duffy. phenotype provides protection from malaria
Fy(a-,b-)
what kind of malaria does Fy(a-,b-) protect against
P. vivax
T or F: the Duffy ags do not show dosage
F
what kind of immunoglobin are Duffy abs
IgG
what chromosome are the Kidd blood group system located on
18
what ags do Jka and Jkb alleles code for
Jk3
what is the phenotype of JkJk
Jk(a-,b-)
what blood group system do enzymes affect
Kidd
Bg ag is on what cell
WBC
The following phenotypes are written incorrectly except for:
a. Jk a +
b. Jka+
c. Jk a (+)
d. Jk(a+)
d
Which of the following characteristics best describes Lewis antibodies?
IgM, naturally occurring, do not cause HDFN
The Le gene codes for a specific glycosyltransferase that transfers a fucose to the N -acetylglucosamine on:
Type 1 precursor chain
What substances would be found in the saliva of a group B secretor who also has Lele genes?
H, B, Le a , Le b
Transformation to Le b phenotype after birth may be as
Le(a– b–) to Le(a+b–) to Le(a+b+) to Le(a– b+)
in what way do lewis ag change during pregnancy
Lea and Leb both decrease
A type 1 chain has:
The terminal galactose in a 1-3 linkage to subterminal N -acetylglucosamine
Which of the following genotypes would explain RBCs typed as group A Le(a+b–)?
A/A Lele HH sese
Anti-Le bH will not react or will react more weakly with which of the following RBCs?
Group A 1 Le(b+)
Which of the following best describes MN antigens and antibodies?
Well developed at birth, susceptible to enzymes, generally saline reactive
Which autoantibody specificity is found in patients with paroxysmal cold hemoglobinuria?
anti-P
Which of the following is the most common antibody seen in the blood bank after ABO and Rh antibodies?
anti-K
The null K o RBC can be artificially prepared by which of the following treatments?
DTT and glycine-acid EDTA
Which antibody does not fit with the others with respect to optimum phase of reactivity?
anti-P1
Which of the following Duffy phenotypes is prevalent in blacks but virtually nonexistent in whites?
Fy(a– b–)
Antibody detection cells will not routinely detect which antibody specificity?
Anti-Kp a
Antibodies to antigens in which of the following blood groups are known for showing dosage?
kidd
Which antibody is most commonly associated with delayed hemolytic transfusion reactions?
anti-Jka
Anti-U will not react with which of the following RBCs?
M+N– S– s–
A patient with an M. pneumoniae infection will most likely develop a cold autoantibody with specificity to which antigen?
I
Which antigen is destroyed by enzymes?
Fya
Which antigen is destroyed by enzymes?
Fya
The antibody to this high-prevalence antigen demon- strates mixed-field agglutination that appears shiny and refractile under the microscope.
Sd a
What red blood cell treatment can be used to differentiate between anti-D and anti-LW?
DTT
Which of the following has been associated with causing severe immediate HTRs?
anti- Vel
Which of the following antibodies would more likely be found in a black patient?
Anti-Cr a
Anti-At a
Anti-Hy
Which of the following antigens is not in a blood group system?
LKE
A weakly reactive antibody with a titer of 128 is neutralized by plasma. Which of the following could be the specificity?
anti-Ch
An antibody reacted with untreated RBCs and DTT- treated RBCs but not with ficin-treated RBCs. Which of the following antibodies could explain this pattern of reactivity?
anti-Ch
The following antibodies are generally considered clinically insignificant because they have not been associated with causing increased destruction of RBCs, HDFN, or HTRs.
Anti-Ch and anti-Kn a
Which antigen is the receptor for Haemophilus influenza?
AnWj
Which antigen is not absent or is weakened on RBCs of individuals with PNH?
Co a
Which of the following blood groups is carried on a structure that helps to maintain the RBC membrane integrity through interaction with protein band 4.1?
Ge
What is the name of the Knops system serologic null phenotype?
Helgeson
Which antigen when absent produces a null in the Dombrock system?
Gy a
Which antigens are strongly expressed on placental tissue, allowing for the adsorption of antibodies?
Cromer
Which antigen was returned to the 901 series because there was no determined linkage to the SMIM1 gene?
ABTI
The FORS blood group system was first thought to be part of what system due to the addition of N -acetylgalactosamine (GalNAc) to the P antigen?
ABO
What glycophorin expresses the MN CHO collection antigens that are associated with altered levels of sialic acid (NeuNAc) or GlcNAc?
GPA
What techniques can be used to remove the reactivity of Bg antigens?
EDTA/glycine-HCL, Platelet adsorption, and Chloroquine treatment
ABTI was thought to be classified with which antigen prior to it gaining system status?
Vel
The Jr(a–) phenotype is found more commonly in:
Japanese.
