Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Metabolism > Review: Simmons > Flashcards

Review: Simmons Flashcards

1
Q

What are amino acids broken into?

A
  1. Nitrogen - becomes urea
  2. Carbon skeletons - glucogenic and ketogenic
  3. Purines & Pyrimidines
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the ketogenic carbon skeletons?

A
  1. AcCoA

2. Acetoacetate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the glucogenic carbon skeletons?

A
  • Pyruvate
  • alpha ketoglutarate
  • Succinyl Co A
  • Fumarate
  • AOA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the source atoms for purine ring?

A

“TAGG”

  1. THF
  2. Asparpate
  3. Glycine
  4. Glutamine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Sources of atoms in pyrimidine ring?

A

“CAG”

  1. CO2
  2. Asparate
  3. Glutamine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Entry point to purine synthesis?

A

Ribose5P from pentose pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is active form of ribose 5 phosphate?

A

PRPP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is branch point for purine synthesis?

A

IMP - will become AMP or GMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is 6 mercaptopurine?

A

Anti tumor agent that blocks purine bionsynthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is 5floro uracil?

A
  • Anti tumor agent that targets Thymadilate synthase

- Blocks DNA synthesis specifically

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What does methyl trexate do?

A
  • Inhibits dihydroflourate reductase
  • Preventing formation of THF
  • Creates folate deficiency
  • DHF levels rise which are toxic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What does dihydroflorate reductase do?

A

Enzyme that makes deoxy ribose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How are purines salavaged?

A

Hypoxanthine and guanine combined with PRPP to create creat nuclueotides: IMP & GMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is Lesch Nyhan syndrom?

A
  • HGRTPase

- Self mutilation disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What happens to purines that are not salvaged?

A
  • Guanine and hypoxanthine are converted to xanthine

- Xanthine converted to uric acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What causes gout?

A

Buildup up of Na urate cyrstale from purine degradation

17
Q

What can excess uric acid cause?

A

Gout or kidney stones

18
Q

How do you treat gout?

A

Alopurinol - blocks xanthine oxidase preventing formation of uric acid

19
Q

What is heme made from ?

A

Succinyl CoA from CAC

Glycine

20
Q

Control of heme pathway?

A
  • Heme provides negative feedback

- As such if there is deficiency there will be no way for negative feedback increasing built up intermediates

21
Q

First enzyme in heme pathway?

A

ALA synthase

22
Q

What should you avoid with heme diseases?

A

The sun

23
Q

What is globine degraded to?

A

AA

24
Q

What is heme degraded to?

A

Biliverdin

25
Q

How does bilirubin travel?

A

Albumin

26
Q

What does hepatocyte do to bilirubin?

A

Conjugates it with glucuronic groups

27
Q

What causes dark color of feces?

A

Bilirubin

Metabolism (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions