Respiratory: Restrictive disease Flashcards

1
Q

What characterizes restrictive disease

A

restricted filling of lungs

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2
Q

what are spirometry values for restrictive disease

A

decrease TLC, FEV1, FVC

FEV1;FVC ratio increased

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3
Q

what are 2 categories what cause restrictive disease

A
  • interstitial disease

- chest wall abnormalities

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4
Q

what is idiopathic pulmonary fibrosis

A

fibrosis of lung interstitium

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5
Q

what is the etiology of idiopathic pulmonary fibrosis

A
  • etiology unknown

- most likely related to cyclical lung injury

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6
Q

cyclical lung injury causes what

A

TGF- Beta from injured pneumoctes induce fibrosis

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7
Q

what are some possible secondary causes of idiopathic pulmonary fibrosis

A
  • drugs: bleomycin and amiodarone

- radiation therapy

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8
Q

what are clinical features of idiopathic pulmonary fibrosis

A

dyspnea

cough

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9
Q

what is seen in lung CT for idiopathic pulmonary fibrosis

A

fibrosis

  • initially seen in subpleural patches
  • eventually results in diffuse fibrosis with end stage ‘honeycomb’ lung
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10
Q

what is the treatment for idiopathic pulmonary fibrosis

A

lung transplantation

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11
Q

what is pneumoconioses

A

interstitial fibrosis due to occupational exposure

- chronic exposure to small particles that are fibrogenic

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12
Q

how does fibrosis occur in pneumoconioses

A

alveolar macrophages engulf foreign particles

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13
Q

what are common small particles that people are exposed to in pneumoconioses

A
  1. carbon dust
  2. silica
  3. beryllium
  4. asbestos fibers
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14
Q

who is carbon dust most likely seen in

A

coal miners

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