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Pathoma > Female Pathology: Vagina > Flashcards

Female Pathology: Vagina Flashcards

1
Q

what is vagina

A

canal leading to cervis

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2
Q

what is epithelium of vagina

A

mucosa lined by non-keratinizing squamous epithelium

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3
Q

what is vaginal adenosis

A

focal persistence of columnar epithelium in upper vagina

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4
Q

what is the epithelium of lower 1/3 vagina during development? what is it derived from

A

squamous epithelium

urogenital sinus

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5
Q

what is epithelium of upper 2/3 vagina during development? What is it derived from?

A

columnar epithelium

Mullerian ducts

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6
Q

describe the vaginal development

A

squamous epithelium grows upward to replace columnar epithelium

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7
Q

who usually gets vagina adenosis

A

females who were exposed to diethylstilbestrol (DES) in utero

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8
Q

what is clear cell adenocarcinoma of vagina

A

malignant proliferation of glands with clear cytoplasm

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9
Q

clear cell adenocarcinoma of the vagina is a complication of what

A

DES-associated vaginal adenosis

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10
Q

What are other DES-induced abnormalities

A

abnormal shape of uterus

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11
Q

what is embryonal rhabdomyosarcoma

A

malignant mesenchymal proliferation of immature skeletal muscle

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12
Q

how often does embryonal rhabdomyosarcoma occur

A

rare

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13
Q

clinical feature of embryonal rhabdomyosarcoma

A

bleeding and grape-like mass protruding from vagina or penis of child ( 5 yrs or less)

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14
Q

another name for embryonal rhabdomyosarcoma

A

sarcoma botryoides

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15
Q

what is a characteristic cell of sarcoma botryoides name? and describe it

A

Rhabdomyoblast

  • cytoplasmic cross-striations
  • positive immunohistochemical staining for desmin and myogenin
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16
Q

what is vaginal carcinoma

A

carcinoma arising from squamous epithelium lining the vaginal mucosa

17
Q

what is vaginal carcinoma usually related to

A

high-risk HPV

18
Q

what is the precursor lesion for vaginal carcinoma

A

vaginal intraepithelial neoplasia ( VAIN)

19
Q

spread of vaginal carcinoma of lower 1/3 vagina goes where

A

inguinal nodes

20
Q

spread of vaginal carcinoma of upper 2/3 vagina goes where

A

regional iliac nodes

Pathoma (38 decks)

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