Male Pathology: Testicular tumors

Question 1

testicular tumors arise from what

Answer 1

germ cells or sex cord-stroma

Question 2

how do testicular tumors usually present on the body

Answer 2

firm, painless testicular mass

cannot be transilluminated

Question 3

how is testicular tumors removed

Answer 3

radical orchiectomy

Question 4

can you biopsy a testicular tumor

Answer 4

no

- due to risk of seeding the scrotum

Question 5

what is the most common type of testicular tumor

Answer 5

germ cell tumor

Question 6

when does germ cell tumor occur

Answer 6

15-40 years

Question 7

risk factors for germ cell tumor

Answer 7

cryptorchidism

Klinefelter syndrome

Question 8

germ cell tumors are divided into what

Answer 8

seminoma and nonseminoma

Question 9

treatment, metastazie and prognosis for seminoma germ cell tumor

Answer 9

radiotherapy
metastasize late
excellent prognosis

Question 10

treatment, metastazie and prognosis for seminoma germ cell tumor

Answer 10

variable response to treatment

metastasize early

Question 11

What is the most common testicular tumor? what does it resemble

Answer 11

seminoma germ cell

ovarian dysgerminoma

Question 12

histo for seminoma germ cell tumor? What does it resemble? what does it form?

Answer 12

• large cells with clear cytoplasm and central nuclei ( resembles spermatogonia)
• forms hemorrhagic mass with no hemorrhage or necrosis

Question 13

in rare cases seminoma germ cell tumor can secrete what hormone

Answer 13

beta-hCG

Question 14

What is prognosis for seminoma germ cell tumor and treatment

Answer 14

good prognosis

radiotherapy

Question 15

Embryonal carcinoma germ cell is composed of what? and forms what

Answer 15

• immature, primitive cells that may produce glands

- forms hemorrhagic mass with necrosis

Question 16

what lab values might be present with embryonal carcinomaq

Answer 16

AFP

beta-hCG

Question 17

What is the most common testicular tumor in children

Answer 17

yolk sac ( endodermal sinus) tumor

Question 18

hist for yolk sac (endodermal sinus)

Answer 18

Schiller-Duval bodies

Question 19

lab values for yolk sac ( endodermal sinus) tumor

Answer 19

AFP elevated

Question 20

what is choriocarcinoma

Answer 20

malignant tumor of syncytiotrophoblasts and cytotrophoblasts ( placenta-like tissue but villi are absent)

Question 21

who does choriocarcinoma spread

Answer 21

blood

Question 22

what hormone is increased in choriocarcinoma? what may this lead to?

Answer 22

beta-hCG

- hyperthyroidism or gynecomastia ( alpha-subunit of hCG is similar to that of FSH, LH , and TSH)

Question 23

what is teratoma tumor composed of

Answer 23

mature fetal tissue derived from 2 or 3 embryonic layers

Question 24

who is teratoma malignant in

Answer 24

malignant in males as opposed to females

Question 25

lab values for teratoma

Answer 25

AFP ro Beta-hCG

Question 26

what is sex-chord stromal tumors

Answer 26

resemble sex cord-stromal tissue of the testicle

usually benign

Question 27

what do leydig cell tumor usually produce? what does this result in?

Answer 27

androgens

- precocious puberty in children or gynecomastia in adults

Question 28

histo for sex-chord tumors

Answer 28

Reinke crystals

Question 29

sertoli cell tumor is comprised of what? clinical manifestation

Answer 29

tubules and clinically silent

Question 30

what is the most common cause of testicular mass in males greater than 60 years old? how does it present

Answer 30

lymphoma

bilaterally

Question 31

what cell type is in lymphoma

Answer 31

diffuse large B-cell type