Kidney/Urinary: Congenital and Acute renal failure Flashcards
What is the most common congenital renal anomaly
horseshoe kidney
What is horseshoe kidney
conjoined kidney usually at lower pole
where is horseshoe kidney abnormally located
lower abdomen
where do normal kidneys develop
pelvis
what problem occurs when horseshoe kidney ascends from pelvis to lower abdomen
get caught on inferior mesenteric artery
what is renal agenesis?
absent kidney formation
- may be unilateral or bilateral
renal agenesis unilateral leads to what consequence?
hypertrophy of existing kidney
- hyperfiltration increases risk of renal failure later in life
renal agenesis bilateral leads to what consequence?
oligohydramnios with lung hypoplasia
Potter’s sequence
What are the symptoms for Potter’s sequence? Is it compatible with life?
flat face
low set ears
developmental defects of extremities
- incompatible with life
what is dysplastic kidney disease
- inherited, congenital malformation of renal parenchyma characterized by cysts and abnormal tissue (cartilage)
what is polycystic kidney disease
- inherited defect leading to bilateral enlarged kidneys with cysts in renal cortex and medulla
what are two forms of polycystic kidney disease (PKD)
Autosomal recessive
Autosomal dominant
autosomal recessive polycystic kidney disease presents in who? How does it present
infants
- worsening kidney failure and hypertension
- newborns present with Potter sequence
autosomal recessive polycystic kidney disease is associated with what congenital abnormality
congenital hepatic fibrosis (leads to portal hypertension)
hepatic cysts
Autosomal dominant polycystic kidney disease presents in who and clinical features
young adults
- hypertension ( due to increase renin)
- hematuria
- worsening renal failure
autosomal dominant polycystic kidney disease is due to what mutation which causes what
APKD1 and APKD2
cysts develop over time
autosomal dominant polycystic kidney disease is associated with what health problems
- berry aneurysm
- hepatic cysts
- mitral valve prolapse
Which congenital kidney problem is not inherited
dysplastic kidney
What happens to the size of kidneys in polycystic kidney disease
enlarged
what is medullary cystic kidney disease inherited
autosomal dominant
what is medullary cystic kidney disease
cysts in medullary collecting ducts
- parenchymal fibrosis results in shrunken kidneys and worsening renal failure
oliguira
low production of urine
azotemia? what lab values are associated with it
increase nitrogen-containing waste products in blood
- increased BUN and creatinine [Cr]