Respiratory Ettinger Flashcards
What can occur in humans with severe nasal resistance?
Cor pulmonale, cardiomegaly, pulmonary edema
What is a very important factor for protection of the alveoli by the nasal cavity?
Conditioning of inspired air by nose
Removal of larger particulate matter
What is the predominant cell type in the nose?
Tall ciliated cells
What is the name for the to and fro movement of the cilia to actively move the mucus blanket?
Ciliary beat
What are the two layers of the mucus blanket in the nose?
The outer layer is more viscid than the deeper, periciliary layer.
Insoluble particles, allergens, and bacteria caught on the outer layer are thus carried to the esophagus. Soluble material reaches the periciliary layer and is absorbed
What is the ultimate cleaning procedure of the nose?
Sneeze (reflex)
What is the pathway for transmission of olfactory information?
Axons of the olfactory receptor cells from olfactory nerves (under mucosa) pass through cribriform plate directly to olfactory bulb (ipsilateral forebrain)
Name an olfactory test.
Activation of brain is recorded by electroencephalographic olfactory analysis
What breed has congenital malformation of the nasal plane?
Brachycephalic breeds
What congenital malformation of the nose can result in intermittent nasal discharge?
Nasal dermoid cysts
Reported in dogs
Fistula in the midline of the bridge of the nose
What congenital abnormality is reported in cats to result in rhinorrhea?
Congenital CSF fistula (reported in one cat) was corrected surgically
What is the consequence of no frontal sinuses?
NOTHING
What is congenital ciliary dysfunction or ciliary dyskinesia?
Ineffective and uncoordinated ciliary function = rhinitis, bronchitis, and pneumonia
Reported in various dog breeds
What is the name of the syndrome when ciliary dyskinesia is associated with situs inversus?
Kartagener’s syndrome
What is the complication of ciliary dyskinesia?
Colonization of mucosa by Pasteurella and Bordetella = Hypoplastic conchae by bone resorption
How can you test for ciliary dyskinesia?
small drop of 99mTc macroaggregated albumin
Not always normal in normal animals
Can be affects by inflammation (not affected by anesthesia)
What are the hallmark signs of primary ciliary dyskinesia on EM?
Lack of outer dynein arms
Abnormal microtubular pattern
Electron-dense core in the basal body
What is the prognosis with primary ciliary dyskinesia?
Guarded = Die of sepsis from recurrent pneumonia Tx = ABX
What type viruses make up 80-90% of infectious upper respiratory infections in cats?
Feline herpesvirus 1 (FHV-1)
Feline Calicivirus
What percentage of cats with URI will become chronic carriers?
About 80% (even if vaccinated with MLV)
When be calcivirus carriers shed?
ALL THE TIME, from the oropharynx
When be herpesvirus carriers shed?
ONLY WHEN SHOWING CS (sneezing and nasal dc)
Name the common causes of mycotic rhinitis in dogs.
Aspergillus spp, occasional Penicillium spp
Name the common causes of mycotic rhinitis in cats.
Cryptococcus neoformans (MOST common, can occur in dogs too) Alternaria spp (proliferation of skin on nasal plane = dyspnea)
What is the most common spp of aspergillus in rhintis in dogs?
A. fumigatus
A. terreus - related to disseminated dz, that can also occur in the nose but is less common
What are the 3 main methods of dx of Aspergillosis?
- Rhinoscopy = plaques
- Culture (normal dogs can be positive)
- Serology (no false positive but can have extensive dz with negative serology)
What percentage of normal dogs can have Aspergillus on nasal cultures?
Up to 40% in normal dogs
What are the 2 main treatments for Nasal Aspergillosis?
Enilconazole or clotrimazole
In dogs with nasal aspergillosis, what was needed to determine the effectiveness of clotrimazole treatment?
Rhinoscopy!
Neither CS nor serology was predictive of disease state
How do you make the diagnosis of Nasal Cryptococcus?
from nasal d/c stained with India Ink (thick and encapsulated)
Need to culture it
What is the treatment for Nasal Cryptococcus?
ketoconazole, itraconazole, fluconazole (at least 8 weeks may be long term)
What is the treatment for Alternia spp in cats?
Proliferative granulomatous crusts that need to be surgically removed from nasal plane, antifungals are NOT helpful :(
What is neurogenic rhinitis?
Unilateral CS: Loss of parasympathetic innervation to nasal glands, associated with ipsilateral KCS, associated with otitis media (resolved with systemic ABX)
Harder if bilateral CS = Needs supportive care only
What are clues for hypoventilation as the cause of hypoxemia?
Increased PaCO2 Normal A-a gradient Absent radiographic infiltrates Ex: Drug-induced depression CNS/PNS disorder Upper airway obstruction
What are clues for VQ Mismatch as the cause of hypoxemia?
Increased A-a gradient Mildly increased PaCO2 Improves with O2 supp Radiographic change common Examples: Bacterial pneumonia Pulmonary edema PTE
What are clues for R→L Shunt
as the cause of hypoxemia?
Increased A-a changes
Fails to improve with O2
Heart/pulm changes common
Ex: RL PDA
Pulmonary AV fistula
Atelectatic lung
What are clues for diffusion impairment
as the cause of hypoxemia?
Marked interstitial ilfiltrates
Improves with O2
Ex: Asbestosis
Idiopathic pulmonary fibrosis
What are clues for reduced FiO2
as the cause of hypoxemia?
Resolves with O2 supplement
Ex: High Altitude
Anesthetic accident
Suffocation
Which intestinal parasites result in migratory through the lungs?
Toxocara, Ancylostoma (verminous pneumonia)
Which parasites are considered pulmonary parenchymal parasites?
Paragonimus kellicotti
Filaroides hirthi, F. milksi
Which parasites are considered airway parasites?
Aelurostongylus abstrusus
Crenosoma vulpis
Oslerus osleri (Filaroides osleri)
Eucoleus aerophilia (Capillaria aerophilia)
For Paragonimus kellicotti:
What is the intermediate host, dx, and tx?
o Great Lakes, Midwest, south; Intermediate host – Crayfish
o Intestine -> subpleural tissue -> migrate/tunnel through bronchioles
o Hemoptysis, pneumothorax, pulmonary bullae & cysts w/in parenchyma;
o *Right caudal lung lobe most commonly affected
o Diagnosis: Airway wash, fecal (sedimentation best) - See picture
o Praziquantel (x3 days), fenbendazole
Which lung lobe is most commonly afefcted with Paragonimus kellicotti
Right caudal lung lobe
For Filaroides hirthi and F. milksi, what is the transmission, dx, and tx?
o Endemic research facilities, oral-fecal transmission (DIRECT)
o Normal vs clinical (young/small breed/immunosuppressed or super infections)
Where is Filaroides hirthi and F. milksi endemic?
Research Facilities
For Aelurostrongylus abstrusus, what is the intermediate host, dx, and tx?
(Feline lung worm)
o Brochiole worms, mimic bronchopulmonary disease
o Intermediate host – Mollusk
o Airway – larva, Baermann sedimentation larva (& PCR pharyngeal swab)
o Fenbend, ivermectin, selamectin
For Crenosoma vulpis, what is the intermediate host, dx, and tx?
Dog only)
o NE USA, East Canada; intermediate host mollusk
o Airway sample, Zn Sulfate, Baermann; Fenben / Iver / Milbemycin oxime
For Oslerus osleri what is the transmission, dx, and tx?
o Distal trachea / proximal carina; DIRECT transmission (young dogs; *Greyhounds)
o Bronchoscopy, Zn sulfate sedimentation; Ivermectin may not clear infection completely
o Larva – kinked tail
What breed should you think of with Oslerus osleri?
Greyhounds