Ettinger COPY Flashcards
Which Th mediates immune mediated disease?
Th2
What factors are involve in:
- intrinsic
- extrinsic
- common
- intrinsic: XII, IX, VIII
- extrinsic: tissue factor, VII
- common: X, V , prothrombin (II), fibrinogen(I), XIII
What test will be prolonged first in rodenticide intoxication?
PT (within 36-72 hours)
Scott syndrome:
- results in ____
- affects ____ breed
Defect procoagulant activity on platelet surface
German Shepherd
Hemophilia
- which factor
- results in
- PT/PTT prolongation
A= VIII B = IX
Inhibit formation of tenase complex
PTT elevation
Which cell provide iron necessary for hemoglobin production?
Macrophages
How long does it takes for reticulocytes release?
2-5 days
Which type of IMHA carries the worst prognosis?
Intravascular
Which genetic erythrocyte enzyme deficiency causes impaired erythrocyte energy metabolism?
- Pyruvate kinase (iron overload)
- Phosphofructokinase defiency
- Hereditary spectrum deficiency
- Genetic membrane disorders
What can result in EPO deficiency
- Kidney (peritubular interstitial cells of inner renal vortex and outer medulla)
- PTH
- Hypoalbuminemia
Why does inflammation results in decreased erythropoiesis?
IL-6 increases production of hepcidin which internalize ferroporrietin, prevent release of iron from macrophages and hepatocytes + blocks intestinal iron absorption
Which does hypocobalaminemia results in abnormal erythropoiesis ?
Impaired DNA synthesis within erythroblast
What mutation is associated with polycythemia Vera?
JAK2
Which cancer can result in secondary polycythemia?
Nasal fibrosarcoma, shwannoma , cecal leiomyosarcoma, renal carcinoma/lymphoma/fibrosarcoma
What are the signs of hyperviscosity?
CNS
Hemorrhage
Pu/PD
Vomiting/diarrhea