GI Ettinger Flashcards
Which cell in the stomach makes intrinsic factor?
Parietal cells
What are the 3 major components of acid secretion?
Histamine, Gastrin, ACh
Which hormone is responsible for decreasing gastrin, histamine, and acid secretion when stomach pH
Somatostatin
What are the components of the gastric mucosal barrier?
§ Tightly opposed epithelial cells § Bicarbonate rich mucous § Abundant mucosal blood supply § Prostaglandins (PGE2) are important in modulating · Blood flow · Bicarbonate secretion · Epithelial cell renewal
What factors slow emptying of stomach?
Carbs, AA, fats
Release of CCK in response to FA and AA
What are the 3 major digestive enzymes in the stomach?
Pepsin (releases as pepsinogen in response to ACh and histamine) Gastric lipase (in response to pentagastrin, histamine, PGE2, and secretin, active in SI) Intrinsic factor (dogs)
Which breeds get hypertrophic gastropathy?
Basenji, small breed dogs (shih Tzu)
Which breed gets atophic gastritis?
Lundehund
What can stoamtocytosis tell you on a CBC?
Stomatocytosis has been described in Drentse Patrijshond dogs with familial stomatocytosis-hypertrophic gastritis
What are causes of metabolic alkalosis?
· Metabolic alkalosis
o Associated with pyloric/duodenal outflow obstruction
o Associated with parvo and pancreatitis
o Gastrinomas
§ Also associated with aciduria
§ hypoCl/K due to gastric acid hypersecretion
Conservation of volume at expense of pH (renal reabsorb HCO3 and exchange Na for H+ = promotes acidic urine (paradoxical aciduria)
What breed when given IV secretin will have a high gastrin level w/o a gastrinoma?
Basenjis (with enteropathies)
What gastric tumors are found in these locations? Pyloric antrum, cardia, diffuse
§ Pyloric antrum · Adenocarcinoma (lesser curvature also) § Cardia · Leiomyoma § Diffuse · LSA
What is the most common site of an adenomatous polyp?
Pyloric antrum
Which breeds are predisposed to PLE?
SCWT, Yorkie, Basenji, Lundehund, Shar-Pei
What AA def can results in high ammonia in cats?
Arginine def
Which coag factor is NOT made by the liver?
Factor VIII
What defines DIC?
Prolonged PT/PTT Decreases fibrinogen thrombocytopenia increased FDPs (all of which can be seen with liver dz too)
What is the most toxic bile acid?
Lithocholic acid
How can diuretics exacerbate HE?
Alkalosis and HypoK!!!
What tropic factors are important for hepatic growth?
Insulin and Glucagon (from portal blood)
What is the toxin in cycad?
Cycasin (converted to MAM (methylazoxymethanol) by GI microbes) and unnamed neuro toxin
What is the MOA of cycad toxin?
Cycasin: MAM results in GI, hepatotoxin, neurotoxin
MAM alkylates DNA/RNA
What are the target organs of cycad toxin?
Cycasin: LIVER, GI, Neuro
What is the clinical presentation of cycad toxin?
Cycasin: within 24 hrs (GI signs and neuro signs)