Kirks And Ettinger Flashcards
Which neoplasia can result in bilateral symmetrical alopecia?
Sertoli cell tumor
Guanidine contrast can be use to highlight which neoplasia?
Pheochromocytoma
Hypotension refractory to fluid resuscitation should make you think of what?
Circi
What are the 3 ways to diagnose CIRCI?
- ACTH stimulation below references range
- post ACTH cortisol < 5% basal
- delta < 3
Congenital hypothyroidism with goiter can be seen in which 2 breeds?
Fox terrier and rat terrier
Which 2 breeds are predisposed to hypothyroidism?
Golden (as soon as 2 y/0) and Doberman
Which 2 breeds are predisposed to myxedema stupor?
Rottweiler and Doberman
Which thyroid hormone is the most protein bound?
T4
Which thyroid hormone results in renal artériole dilation?
T3
What is the mechanism of action of methimazole?
Inhibit thyroid peroxidase ( delay of 2-4 weeks given the presence of preformed hormones)
Name 4 other anti thyroid medication?
1- propylthiouracil
2- carbimazole
3- b- blocker (inhibit conversion of T4 to T3)
- iopanoic acid
I-131 concentrate in thyroid gland and emits _____
B particles
What is the renal glucose threshold in dogs ?
180-220
What should the nadir be in dogs with DM ?
80-150
What is the best type of diet for cats with DM?
High proteins, low carbohydrates
Which protein stimulate endogenous insulin the most in cats?
Arginine
What are the 2 types of insulin associated with higher chances of remission?
Glargin
Detemir
why do diabetes results in neuropathy? in cataracts ?
- Accumulation of fructose in nerves results in demyelination
- Accumulationof sorbitol within the lens
Which ketones does dipstick measure?
acetone and acetoacetate
Why electrolytes are decrease in DKA ?
Potassium, phosphorus and magnesium
At which dose of insulin should we consider insulin resistance ?
1.5 UI/kg
What are the 3 diseases that results in severe insulin resistance ?
HAC, acromegaly and diestrus
What are the 2 etiologies of hypersomatotropism ?
Acidophilic hyperplasia and pituitary adenoma
In regards to testing for Cushing disease, ACTH stimulation is more ____ whereas LDDST is more ____
Specific
Sensitive
What is the mechanism of action of mitotane
Necrosis of the zona fasciculata and reticularis
What is the mechanism of action of trilostane ?
Competitive inhibitor of steroid synthesis by blockin 3B-hydroxysteroid dehydrogenase
Why drug can interact with trilostane ?
Spironolactone
Ectopic ACTH syndrome is associated with which 2 diseases ?
Lung carcinoma
Neuroendocrine tumors
Secondary hypoadrenocorticism results in atrophy of ____
the zone fasciulata
Primary hyperaldosteronism results in hyperfunction of _____
zone glomerulosa
What is the medical management of hyperaldosteronism ?
Amlodipine, spironolactone and K+ supplementation