Respiratory 7 Flashcards
Amount of oxygen bound to Hb depends on
Plasma O2 (RBC and cytosol PO2) and amount of hemoglobin
What does plasma O2 determine
% saturation of Hb
Plasma O2 is determined by
Alveolar PO2
What does alveolar PO2 depends on
1, composition of inspired air
2. Alveolar ventilation rate
3. Efficiency of gas exchange (normal for healthy)
What does the amount of hemoglobin determine
Amount of Hb binding sites
What is the total number of Hb binding sites calculated from
Hb content per RBC x Number of RBCs
What is anemia
Reduced carrying capacity of O2 in blood
What is the amount of O2 bound to Hb at any given PO2 expressed as
Percent saturation of hemoglobin (for any given pO2, Hb is a certain % saturated)
What determined the % saturation of Hb
PO2 that Hb is exposed to
What type of cells can have a lower PO2
Active cells (curve steep)
Can be as low as 20mmHg but larger release of O2
If PO2 100 how saturated us Hb
98.5%
When does more significant changes in saturation begin
Po2 below 60 mmHg
What physical factors alter hemoglobin’s affinity for O2
Levels of CO2, pH, temperature, 2,3-BPG
Shift in hemoglobin saturation as a result in pH or CO2 change
Bohr effect
What causes fast decreasing shift in pH
Active cells (max exertion)
- produces excess CO2, results in increased H+ and lactic acid in cytoplasm and extracellular space
- decrease pH, high acid, slight conformation in Hb