respiratory Flashcards
surfactant secreting cells
Type II pneumocytes(cuboidal)
foreign body lung
right inferior lobe
methemoglobin
Fe3+(cyanide binding), Tx-methylene blue
pulmonary HTN pressure
> 25mmHg
primary pulmonary HTN gene
BMPR2(vascular smooth muscle proliferation)
virchows triad
stasis, hypercoagulability, endothelial damage
postpartum DIC
amniotic fluid embolism
fat embolism triad
hypoxemia, neuro, petechial rash
pre-death thrombus pathology
lines of zahn
low FEV/FVC ratio
obstructive lung disease(emphysema/bronchitis/asthma)
A1AT emphysema pathology
panacinar(smoking=centriacinar)
asthma pathology
curschmann spirals, charcot-leyden crystals
anthrax, silicon & asbestos lobes
anthrax&silicon-upper, asbestos-lower
trachial deviation causes
towards-atelectasis&pneumothorax, away-tension pneumo
adenocarcinoma gene
k-ras(most common in nonsmokers)
nasal polyps associations
cystic fibrosis, ASA-resistant asthma
nasopharyngeal carcinoma association
EBV(african kids chinese adults)
laryngeal papilloma association
HPV 6&11
atypical pneumonia pathology
interstitial(viral)
most common secondary pneumonia
staph aureus
lobar pneumonia causes
strep p, klebsiella
silver stain bug
legionella
aspiration pneumonia bugs
bacteroides, fusobacterium, peptococcus (right lower lobe)
primary TB
Ghon(calcified complex) lower lobe +hilar lymph nodes, asymptomatic
secondary TB
apex+symptoms
cytokine inducing fibrosis
tgf-beta
coal pneumoconiosis association
rheumatoid arthritis
plexiform lesions
long term pulmonary HTN
ARDS pathology
hyaline membrane, leaked protein
surfactant neonatal screening
Lecithin/sphingomyelin >2
lung cancer Tx
small cell=chemo, non=surgery
small cell cancer association
ADH, ACTH, Lambert Eaton
squamous cell cancer association
PTHrP
carcinoid test
chromogranin+(neuroendocrine)
reid index >50%
bronchitis(excess mucous glands)
A1AT allele
piZ=dysfunctional
A1AT breathing
pursed lips(pink puffer)
asthma associated cytokines
TH2- IL4(IgE),5(eosinophils),10(inhibit TH1)
kartageners defect
dynein arm of cilia
asthma challenge test
methacholine(muscarinic agonist)
1st line for chronic asthma
corticosteroids(inactivate NF-kB, decrease TNFa)
acute asthma Tx
albuterol(beta2agonisy)
COPD Tx
tiotropium(muscarinic antagonist)
aspirin induced asthma Tx
antileukotrienes(montelukast, zafirlukast)