Pharm extra Flashcards
hyperTG Tx, MOA, SE
fibrates, LPL upregulation, myositis(+gallstones&liver)
low HDL Tx, MOA, SE
niacin, reduce VLDL secretion, flush/gout/acanthosis nigra
high LDL Tx, MOA, SE
HMGCoA(inh to mevalonate), rhabdo(+liver)
hypoglycemic toxicity DM drugs
2nd gen sulfonylureas(gli), insulins, amylin analog(lintide)
lactic acidosis toxicity DM drug
metformin
weight gain/HF toxicity DM drug/MOA
glitazones(PPARgamma-insulin sensitivity)
disulfiram-like RXN DM drugs
1st gen sulfonylureas(amides)
longish acting insulins
glargine, detemir, NPH
TNF-alpha inhibitors
infliximab, adalimumab, etanercept
HIT coag 2nd line
rudins-inhibit thrombin
ACS/stenting 2 options
ADP-R(grels/ticlodipine), GPIIb/3A Inh(abcmab/fIIbs)
claudication drugs
cilostozol, dipyridamole(phospho III inhibitors)
MTX vs 5FU toxicity
leucovorin vs thymidine rescue
cyclophosphamide MOA, SE+Tx
link guanine N-7, hemorrhagic cystitis-prevent w/mesna
pulmonary HTN Tx, MOA
bosenten-endothelin1 inhibit
reduce uterine contractions, MOA
terbutaline-beta2-agonist
clomiphene use&MOA
infertility/PCOS, partial agonist SERM
emergent glaucoma Tx
pilocarpine-increase outflow contracting ciliary muscle
random opiods
meperidene, diphenoxylate, dextromethorphan, butorphanol
stevens-johnson drugs
carbamazepine, ethosuxamide, phenytoin, lamotrigine
barbiturates(include thiopental) vs benzos MOA
increase duration of Cl- channel opening vs increasing frequency= increase in GABA in both
NMDA block anesthesia
ketamine(PCP analog)
succinylcholine MOA, OD Tx, similar agents
sustained NM depolarization, ACh-esterase inh(neostigmine) but only in phase 2. curiums
dantrolene use
malignant hyperthermia+neuroleptic malignant syndrome
benztropine, selegine/capones, amantadine, ldopa, bromocriptine/pramiprexole/ropinarole use+MOA
parkinsons-antiM(tremor), MAOB inh(less dopa degraded), inc dopa release, dopa, dopa agonists
reserpine/tetrabenzine, haloperidol use+MOA
huntingtons-inhibit VMAT(limit dopa release), dopaR ant
sumatriptan contraindication
CAD/prinzmetal(causes vasospasm)
memantine, donepezil/galantamine/rivastigmine use+MOA
alzheimers-NMDA antagonist, ACh esterase inhibitors
alcohol withdrawal Tx
benzos(pams/lams/chlordiazepoxide)
trifluoperazine, fluphenazine, haloperidol MOA&SE(TFH)
D2 block high potency-EPS(kinesias)H=NMS+tardive
thioridazine, chlorpromazine SE
low potency-alpha/H/cholinergic SE, reTinal, Corneal
weight gain drugs+other SE
clozapine/olanzapine-atypicals, c=agranulocyte+seizure
long QT drug+other atypicals
ziprasidone(quietapine, risperadone, aripiprazole)
heart block drug, other SE
lithium-tremor, hypothyroid, polyuria, ebsteins in kids
anxiety med for alcoholics, MOA
buspirone-5HT1A
iptyline/ipramine, doxepin, amoxepine SE+Tx
3Cs(cardio/convulsion/coma), NaHCO3
seratonin sydrome causes, Tx
SSRI, SNRI, TCA, MAO, cyproheptadine
venlafaxine, duloxetine MOA+SE
SNRI-high BP+stimulant effects
MAO inhibitors+SE
MAO Takes Pride In Shanghai-Tranylcypromine, phenelzine, isocarboxazid, selegine, HTN crises
mirtazapine, maprotiline, trazodone MOAs/SE
a2+5HT2/3 antagonist-weight gain/sedation, NERI-hypotension, serotonin reuptake-PRIAPISM
