MSK Flashcards by Colin McDonald

junctional loss promotes metastasis

cadherins

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desmosome autoantibodies

pemphiigus vulgaris(acantholysis-separation)

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hemidesmosome autoantibodies

bullous pemphigoid

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pregnancy nerve block

pudendal(ischial spine)

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ulnar lesion in the wrist

hook of hamate/pisiform

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axillary injury locations

surgical neck of humerus/dislocation

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radial injury locations

crutches, midshaft humerus fracture, subluxed radial head

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fibular neck Fx

common fibular nerve(foot drop)

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rigor mortis cause

lack of ATP

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achondroplasia mutation

autosomal dominant FGFR3 activating

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osteosarcoma lesions

codman’s triangle, sunburst X-ray(metaphysis)

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ewings sarcoma gene

11,22 translocation

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ewings sarcoma pathology

onion skin, blue cells on diaphysis, kids(neuroectoderm derived)

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osteochondroma pathology

cartilage cap(metaphysis)

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giant cell tumor lesion

double bubble X-ray(only epiphysis tumor)

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Rheumatoid hand involvement

No DIPs

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RA gene

HLA-DR4 (IgM against Fc portion of IgG)

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sjogrens triad

dry eyes, dry mouth, arthritis

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sjogrens antibodies

SS-A(Ro), SS-B(La)

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pseudogout pathology

calcium pyrophosphate, positive birefrigence

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HLA-B27 associated arthropaties

ankylosing spondylitis, psoriatic, IBD, Reiter’s(cant see/pee/climb a tree-post infectious)

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SLE common COD

nephritis

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sarcoidosis lesions

bilateral hilar adenopathy (with noncaseating granulomas)

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poly/dermatomyositis labs(proximal weakness+facial rash)

anti-Jo, ANA, high CK

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myasthenia gravis antibodies

postsynaptic ACh receptor

lambert eaton antibodies

presynaptic Ca channel

MG association

thymoma/thymic Cancer

LE association

small cell lung cancer

scleroderma antibody

Scl-70(DNA topoisomerase 1), CREST=anti centromere

genital warts causes

syphillis, HPV 6,11(verrucae/condyloma)

pemhigus antibodies

desmoglien 3

dermatitis herpetiformis deposits

IgA(celiac association)

target lesion

erythema multiforme(or lyme)

skin mucous membrane drug reactions

Stephens-Johnson, Toxic epidermal necrolysis

acanthosis nigricans associations

hyperinsulinemia, malignancy

actinic keratosis risk

squamous cell carcinoma

erythema nodosum associations

crohns, sarcoid, mycoB/histo/strep/coccidio

lichen planus association

hepatitis C(6 P's-purple, pruritic, planar, polygonal, plaques, papules, sawtooth junction)

Hairy leukoplakia cause

EBV(often HIV+)

most common skin cancer

basal cell(palisading nuclei, rare metastasis)

squamous cell cancer pathology

keratin pearls

melanoma genetics

s-100 marker, BRAF mutations

aspirin MOA

acetylate both COX1&2

aspirin toxicity

GI bleed/tinnitus, Reye's(kids with virus)

COX2 risk

thrombosis

acetominophen difference

No anti-inflammatory(only analgesic/antipyretic) use for kids

acetominophen toxicity

loss of glutathione(give n-acetyl cysteine)

TNF alpha inhibitors

inflixamab, adalimumab, etanercept

chronic gout choices

xanthine oxidase inhibitors(allopurinol/febuxistat), inhibit PCT resorption(probenacid), bind tubulin inhibit polymer (colchicine)

osteogenesis imperfecta defect

autosomal dominant collagen type 1(blue sclera-choroidal veins)

osteopetrosis mutation

carbonic anhydrase II

osteopetrosis Tx

bone marrow transplant

paget disease of bone risks

high output heart failure, osteosarcoma

vertebral TB infection

potts disease

gardner syndrome pathology

facial osteoma, FAP, fibromatosis of peritoneum

pathology difference between dermato/polymyositis

dermato=perimysium, poly=endomysium

x-linked muscular dystrophy gene

dystrophin(muscle replaced by adipose, calf pseudohypertophy)

most common soft tissue tumors

lipoma, liposarcoma(malignant), rhabdomyosarcoma(kids)

rhabdomyosarcoma test

desmin+(head/neck/vagina)

atopic dermatitis(eczema) hypersensitivity

type I(asthma/allergic rhinitis associated)

psoriasis gene

HLA-C

psoriasis sign

auspitz sign(bleed on scrape)

multiple seborrheic keratoses sign

leser-trelat-GI carcinoma

xeroderma pigmentosum defect

nucleotide excision repair(autosomal recessive)

keratoacanthoma(fast growing SCC) Tx-

NONE-spontaneous regression

melanin precursor

tyrosine

high ALP disease

pagets

posterior duodenal ulcer lesion

gastroduodenal artery bleed

CN autonomic ganglia/functions

otic-parotid gland, geniculate-VII sensory(2/3taste), submandibular-sublingual/submandibular gland, PPG-lacrimal&nasal secretions