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Board Associations > MSK > Flashcards

MSK Flashcards

1
Q

junctional loss promotes metastasis

A

cadherins

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2
Q

desmosome autoantibodies

A

pemphiigus vulgaris(acantholysis-separation)

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3
Q

hemidesmosome autoantibodies

A

bullous pemphigoid

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4
Q

pregnancy nerve block

A

pudendal(ischial spine)

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5
Q

ulnar lesion in the wrist

A

hook of hamate/pisiform

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6
Q

axillary injury locations

A

surgical neck of humerus/dislocation

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7
Q

radial injury locations

A

crutches, midshaft humerus fracture, subluxed radial head

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8
Q

fibular neck Fx

A

common fibular nerve(foot drop)

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9
Q

rigor mortis cause

A

lack of ATP

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10
Q

achondroplasia mutation

A

autosomal dominant FGFR3 activating

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11
Q

osteosarcoma lesions

A

codman’s triangle, sunburst X-ray(metaphysis)

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12
Q

ewings sarcoma gene

A

11,22 translocation

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13
Q

ewings sarcoma pathology

A

onion skin, blue cells on diaphysis, kids(neuroectoderm derived)

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14
Q

osteochondroma pathology

A

cartilage cap(metaphysis)

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15
Q

giant cell tumor lesion

A

double bubble X-ray(only epiphysis tumor)

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16
Q

Rheumatoid hand involvement

A

No DIPs

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17
Q

RA gene

A

HLA-DR4 (IgM against Fc portion of IgG)

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18
Q

sjogrens triad

A

dry eyes, dry mouth, arthritis

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19
Q

sjogrens antibodies

A

SS-A(Ro), SS-B(La)

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20
Q

pseudogout pathology

A

calcium pyrophosphate, positive birefrigence

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21
Q

HLA-B27 associated arthropaties

A

ankylosing spondylitis, psoriatic, IBD, Reiter’s(cant see/pee/climb a tree-post infectious)

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22
Q

SLE common COD

A

nephritis

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23
Q

sarcoidosis lesions

A

bilateral hilar adenopathy (with noncaseating granulomas)

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24
Q

poly/dermatomyositis labs(proximal weakness+facial rash)

A

anti-Jo, ANA, high CK

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25
Q

myasthenia gravis antibodies

A

postsynaptic ACh receptor

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26
Q

lambert eaton antibodies

A

presynaptic Ca channel

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27
Q

MG association

A

thymoma/thymic Cancer

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28
Q

LE association

A

small cell lung cancer

29
Q

scleroderma antibody

A

Scl-70(DNA topoisomerase 1), CREST=anti centromere

30
Q

genital warts causes

A

syphillis, HPV 6,11(verrucae/condyloma)

31
Q

pemhigus antibodies

A

desmoglien 3

32
Q

dermatitis herpetiformis deposits

A

IgA(celiac association)

33
Q

target lesion

A

erythema multiforme(or lyme)

34
Q

skin mucous membrane drug reactions

A

Stephens-Johnson, Toxic epidermal necrolysis

35
Q

acanthosis nigricans associations

A

hyperinsulinemia, malignancy

36
Q

actinic keratosis risk

A

squamous cell carcinoma

37
Q

erythema nodosum associations

A

crohns, sarcoid, mycoB/histo/strep/coccidio

38
Q

lichen planus association

A

hepatitis C(6 P’s-purple, pruritic, planar, polygonal, plaques, papules, sawtooth junction)

39
Q

Hairy leukoplakia cause

A

EBV(often HIV+)

40
Q

most common skin cancer

A

basal cell(palisading nuclei, rare metastasis)

41
Q

squamous cell cancer pathology

A

keratin pearls

42
Q

melanoma genetics

A

s-100 marker, BRAF mutations

43
Q

aspirin MOA

A

acetylate both COX1&2

44
Q

aspirin toxicity

A

GI bleed/tinnitus, Reye’s(kids with virus)

45
Q

COX2 risk

A

thrombosis

46
Q

acetominophen difference

A

No anti-inflammatory(only analgesic/antipyretic) use for kids

47
Q

acetominophen toxicity

A

loss of glutathione(give n-acetyl cysteine)

48
Q

TNF alpha inhibitors

A

inflixamab, adalimumab, etanercept

49
Q

chronic gout choices

A

xanthine oxidase inhibitors(allopurinol/febuxistat), inhibit PCT resorption(probenacid), bind tubulin inhibit polymer (colchicine)

50
Q

osteogenesis imperfecta defect

A

autosomal dominant collagen type 1(blue sclera-choroidal veins)

51
Q

osteopetrosis mutation

A

carbonic anhydrase II

52
Q

osteopetrosis Tx

A

bone marrow transplant

53
Q

paget disease of bone risks

A

high output heart failure, osteosarcoma

54
Q

vertebral TB infection

A

potts disease

55
Q

gardner syndrome pathology

A

facial osteoma, FAP, fibromatosis of peritoneum

56
Q

pathology difference between dermato/polymyositis

A

dermato=perimysium, poly=endomysium

57
Q

x-linked muscular dystrophy gene

A

dystrophin(muscle replaced by adipose, calf pseudohypertophy)

58
Q

most common soft tissue tumors

A

lipoma, liposarcoma(malignant), rhabdomyosarcoma(kids)

59
Q

rhabdomyosarcoma test

A

desmin+(head/neck/vagina)

60
Q

atopic dermatitis(eczema) hypersensitivity

A

type I(asthma/allergic rhinitis associated)

61
Q

psoriasis gene

A

HLA-C

62
Q

psoriasis sign

A

auspitz sign(bleed on scrape)

63
Q

multiple seborrheic keratoses sign

A

leser-trelat-GI carcinoma

64
Q

xeroderma pigmentosum defect

A

nucleotide excision repair(autosomal recessive)

65
Q

keratoacanthoma(fast growing SCC) Tx-

A

NONE-spontaneous regression

66
Q

melanin precursor

A

tyrosine

67
Q

high ALP disease

A

pagets

68
Q

posterior duodenal ulcer lesion

A

gastroduodenal artery bleed

69
Q

CN autonomic ganglia/functions

A

otic-parotid gland, geniculate-VII sensory(2/3taste), submandibular-sublingual/submandibular gland, PPG-lacrimal&nasal secretions

Board Associations (22 decks)

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