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Board Associations > Pharm > Flashcards

Pharm Flashcards

1
Q

Gonorrhea/chlamydia Tx

A

ceftriaxone+azithromycin(or doxycyclin)

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2
Q

clozapine

A

dopamine antagonist

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3
Q

alprazolam

A

GABA agonist

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4
Q

amitryptilene

A

norepinephrine/seratonin reuptake inhibitor

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5
Q

sertraline

A

seratonin reuptake inhibitor

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6
Q

phenelzine

A

MAO inhibitor

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7
Q

decreases L-dopa effectiveness

A

vitamin B6

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8
Q

estrogen effects on thyroid

A

decrease TBG(increase total T)

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9
Q

vinblastine cell cycle affects

A

M phase

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10
Q

acyclovir relies on

A

thymidine kinase phosphorylation

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11
Q

cyclosporin MOA

A

inhibits calcineurin

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12
Q

zero order(constant)elimination kinetics drugs

A

phenytoin, ethanol, salicylates

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13
Q

cocaine during pregnancy

A

placental abruption&IU growth restriction

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14
Q

beta lactams

A

penicillin, carbapenems, cephalosporins, cephamycins, monobactams(aztreonam)

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15
Q

beta lactamase inhibitors

A

clavulonic acid, sul/tazobactam

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16
Q

vancomycin MOA

A

prevents cross linking of d-ala(Gram+)

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17
Q

daptomycin MOA

A

aggregates in membrane PTG, disrupts ion gradient(G+)

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18
Q

aminoglycosides activity, MOA&examples

A

(G-aerobes) irreversably bind 30s, neo/strepto/gento/ tobramycin, amikacin

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19
Q

tetracycline activity, MOA, resistance

A

binds tRNA at 30s ribosome(Ompf gene=resist)(cyclines)

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20
Q

linezolid MOA, activity

A

binds 23s initiation complex of 50s ribsome(resistant G+)

21
Q

antimetabolite drugs(folic acid dihydropterate synthetase)

A

sulfonamide, trimethoprim, dapsone

22
Q

quinolone MOA/toxicity

A

inhibit topoisomerase II (gyrase) or IV, cartilage damage

23
Q

community acquired pneumonia 1st line

A

macrolides/doxycycline

24
Q

hospital acquired pneumonia/catheter UTI 1st line

A

fluoroquinolones (floxacins)

25
Q

rifampin MOA

A

inhibits RNA polymerase(G+cocci, meningitis prophylaxis), orange urine

26
Q

TB combo

A

rifampin, isoniazid, pyrazinamide, ethambutol

27
Q

doxycycline 1st line for

A

rickettsia, spirochetes, chlamydia, brucella (also a choice for anthrax, plauge, tularemia, legionella)

28
Q

macrolide/ketolide MOA

A

23s methylation of 50s subunit (romycins) inhibit peptidyltransferase

29
Q

often 2nd line(similar coverage) to penicillin(resistance)

A

macrolides

30
Q

common CDiff cause

A

clindamycin

31
Q

1st line staph aureus

A

penicillin(often oxacillin due to high resistance rate)

32
Q

syphillis 1st line

A

penicillin G

33
Q

gonnorhea/chlamydia 1st line

A

ceftriaxone+doxycycline OR azithromycin

34
Q

ethionamide/isoniazid MOA

A

inhibit mycolic acid synthesis

35
Q

ethambutol MOA

A

inhibit arabinogalactin synthesis

36
Q

amphotericin B MOA&activity

A

binds ergosterol& leaks(fungal, fluconazole/miconazole similar)

37
Q

albendazole MOA

A

binds colchicine preventing microtubule assembly

38
Q

HIV cocktail

A

2NRTI+1NNRTI or 2+1 protease inhibitor

39
Q

NRTI MOA

A

deoxynucleotide analogs w/ no 3’ end, inhibit chain

40
Q

Na/K ATPase drug

A

digoxin/digitalis-cardiac glycosides-increase contractility

41
Q

chloramphenicol MOA/toxicity

A

bind 50s, gray baby syndrome, aplastic anemia(cheap)

42
Q

sulfonamide MOA/toxicity

A

inhibit dihydropterate synthase, kernicterus(kids), nephrotoxicity, hemolysis in G6PD deficiency

43
Q

flu Tx/MOA

A

zanamivir/oseltamivir-inhibit neuraminidase(decrease viral release)

44
Q

RSV/hep C Tx/MOA

A

ribavirin-inhibit guanine nucleotide synthesis(IMP dehydrogenase inhibitor)

45
Q

CMV 1st&2nd line Tx

A

ganciclovir(inhibits viral DNA polymerase), forscarnet(also 2nd line HSV)

46
Q

inhibit acetylaldehyde dehydrogenase(drunk quicker)

A

disulfirum-like(metronidazole, sulfonylureas)

47
Q

prolonged QT antibiotics

A

Macrolides(especially erythromycin)

48
Q

nephrotoxic antibiotics

A

aminoglycosides, vancomycin

49
Q

gout Tx

A

acute-NSAIDS/colchicine, prophylaxis-allopurinol/probenacid

Board Associations (22 decks)

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