Repro Flashcards
teratogenic period
weeks 3-8
conyloma association
HPV 6&11
koilocytic change
HPV
HPV 16, 18 lesions
dysplasia-intraepithelial neoplasia, progress to carcinoma
thin white vulvar skin vs thick white
lichen sclerosis, lichen simplex chronicus (rule out carcinoma)
paget’s disease vs. melanoma labs
paget=PAS+ keratin+ S100-, melanoma opposite
female reproductive tract derivation
mullarian duct(paramesonephric)
vaginal adenosis association
DES in pregnancy(persistent columnar epithelium) then possible clear cell adenoma
grape-like mass
rhabdomyosarcoma(desmin&myogenin+)
vaginal cancer spread
lower 1/3=inguinal, upper 2/3=iliac
HPV virus type& high risk protein targets
DNA, e6=p53, e7=Rb
complication of cervical cancer
bladder invasion
asherman syndrome lesion
post procedural uterine adhesions(loss of basalis)
endometrial polyp cause
tamoxifen
unopposed estrogen causes
endometrial hyperplasia(possibly endometroid carcinoma)
sporadic endometrial cancer lesion
p53, serous papillae on atrophic endometrium
psammoma body causes
papillary cancer thyroid, papillary sporadic endometrial, meningioma, mesothelioma
leiomyoma vs leiomyosarcoma
multiple white whorled vs. one hemorrhaging
endometriosis common lesions
ovary chocolate cysts, uterus/pouch of douglas/fallopian, soft tissue gunpowder lesions
theca cell function
LH causes androgen production
granulosa cell function
FSH converts androgen to estrogen(egg maturation)
corpus luteum function
secrete progesterone
polycystic ovarian syndrome
increased LH(LH:FSH>2) associated to T2DM(fat)
BRCA1 reproductive tumors
serous carcinoma of ovary/fallopian tubes
brenner tumor characteristic
urothelium cells
most common germ cell tumor in females
cystic teratoma
most common malignant germ cell tumor
dysgerminoma(looks like egg, high LDH)
endodermal sinus tumor pathology
schiller-duvall bodies, high AFP, mimics yolk sac(most common in kids)
choriocarcinoma lab
high bHCG(small and hemorrhagic fast spread)
granulosa-theca cell tumor lab
excess estrogen
reinke crystals(pink) tumor type
leydig
fibroma association
pleural effusion, ascites(Meigs syndrome)
bilateral krukenberg tumor association
mucinous tumor(especially gastric carcinoma)
pseudomyxoma peritonii lesions
primary appendix tumor+mucinous ovarian
ectopic pregnancy risk factors
PID, endometriosis(scarring)
preeclampsia triad
HTN, proteinuria, edema(seizures=ecclampsia-deliver)
HELLP
hemolysis elevated liver enzymes low platelets(liver microangiopathy is cause)
passing grapelike masses
hydatidaform mole (snowstorm US)
partial mole features
69(two sperm+mom)+fetal tissue
complete mole features
46(just two sperm) all villi edematous, high risk
hypospadias embryology
failure of urethral folds to close
epispadias embryology/association
abnormal genital tubercle positioning, bladder exstrophy
lymphogranuloma venerum bug&pathology
Chlamydia L1-3(obligate intra), necrotizing lymph nodes
cryptorchidism association
sterility, seminomas
orchitis/prostatitis bugs
chlamydia/gonorrhea, ecoli/pseudamonas adults, mumps
hyrdocele fluid location
tunica vaginalis(improper closure of processus vaginalis)
seminoma pathology
large clear cells(good prognosis) Tx-radiotherapy
embyonal pathology
necrotic/hemorrhagic primitive cells(chemo-sometimes differentiates) high AFP/bHCG sometimes
most common kids tumor+labs
yolk sac, high AFP, schiller duval(glomerulus like)
choriocarcinoma lab/side effects
high bHCG-gynecomastia/hyperthyroid
teratoma male vs female
benign in F, malignant in M
most common testicular mass cause in old men
diffuse large Bcell lymphoma
BPH Tx
a1 antagonist/5a reductase
most common cancer in men
prostatic adenocarcinoma(posterior periphery) PSA>10
cancer NOT to biopsy in men
testicular-most malignant
prostate cancer spread
lumbar-osteoblastic metastastes(Tx-androgen inh/GnRH analog)
periductal mastitis association
smoking(vit A deficiency), nipple retraction
green-brown nipple discharge
mammary duct ectasia
normal breast change
fibrocystic-blue dome cysts(apocrine metaplasia NO cancer risk)
bloody nipple discharge
intraductal papilloma papillary carcinoma(no myoepithelial)
most common mass
fibroadenoma-change with estrogen
comedo ductal CIS
central necrosis/calcification(pagets if reaches nipple)
BRCA1 lesion
medullary carcinoma
lobular carcinoma in situ pathology
lacking E cadherin(risk factor, Tx-tamoxifen)
Tx-response for breast cancer based on
Estrogen/progesterone(tamoxifen), Her2Neu(trastuzamab) receptors
male breast cancer
BRCA2/klinefelters(ductal carcinoma)
gynecomastia causes
spirinolactone, digitalis, cimetadine, alcohol, ketaconazole
GnRH analog drug
leuprolide
BPH Tx&MOA
finasteride-5-alpha reductase inhibitor or tamsulosin-a1ant
ketoconazole use&MOA
PCOS hirsuitism-inhibit 17,20 desmolase(steroid synthesis)
abortificants
mifepristone&misoprostol(PGE1)