resp onc 6 Flashcards
MEN 1
parathyroid
pituitary
pancreas (insulinoma, Zollinger etc)
MEN 2A
medullary thyroid
pheo
parathyroid
mechanism of rifampin
inhibits dna dep merase to stop DNA synt
inhibits arabinosyl transferase
ethambutol
pyrazinamaide
inhibits FA synthase 1
how to treat hemorrhagic cystitis by cyclophosphamide
mesna ( binds toxic metabolites)
what is dexrazoxane used for
iron chelator … avoid toxicity by doxorubicin
risk factors for nasopharyngeal carcinoma
Asian, male, high salt meat and fish diet …
EBV hhv4
HIV pt … stopped HAART and has rash on face arms and legs
reddish purple raised nodules … what are these
kaposi sarcoma HHv8 … AIDs defining illness
Kaposi sarcoma most like other assoc
black stools
cyanide mechanism of action
binds cytochrome oxidase … stops electron transport chain…. cellular resp halter
antidote for cyanide poisoning and its mechanism
hydroxycobalamin … binds cyanide directly
methemoglobinemia… with nitrite
thiosulfate
history of contruction work, dyspnea, pleural thickening
mesothelioma
assoc with asbestosis … only pneumoconiosis with upper lobe affected
yellow brown shape bodies with clubbed ends and stain with Prussian blue
heart failure pt wat can be seen in alveoli (histo)
hemosiderin laden macrophages
occupation that involves asbestos exposuire
shipyard, plumbing and insulation installation
leuprolide mechanism
GnRH inhibition ….. low LH FSH levels
GHRH antaginst name
somatostatin
deadly cancer men
lung prostate and colorectal
deadly cancer women
lung breast colon
most common cancer men
prostate lung and colon
most common cancer women
breast lung colon
woman breast cancer metastasis and surgery presents with tachycardia tachypnea and pleuritic chest pain
PE …. cancer can increase risk of coagulation
mucus plugs form in assoc with which genetic condition
CF chromosome 7 phe508 protein misfolding
why is sarcoidosis assoc with increase calcium
activats 1 alpha hydroxylase within the macrophages that makes active vit D form \
ant uveitis, polyarthritis, lymphadenopathy
productive cough, abd pain, diarrhea and hyponatremia
charcoal extract yeast agar …. legionella
can legionella cause TTP
yes …anticodies crossreact with ADAM TS13 an enzyme that degrades vWF …
5FU, methotrexate and 6mercaptopurin
S phase
bleomycin
g2 phase
Thayer martin
N gonorrhea
bilateral symmetrical peribronchiovascular alveolar processes in a transplant patient …. what infection??
CMV env linear DsDNA
LATENT in mononuclear cells
non env linear DsDNA
adeno
how to terminate pregnancy and treat choriocarcinoma a trophoblastic disease
methotrexate … s phase ….
what causes an increase in 2BPG
compensatory mechanism of high altitude for ex
pt with leogeneires disease risk factors
older pts smoking alcohol diabetes cronic illness
silicosis vs desquamative interstitial pneumonia
History very imp … check for work places silicosis usually work in foundries, sandblasting, glass etc
what kind of necrosis can be seen in aspiration pneumonia
liquefactive necrosis
RB gene function
binds to E2F that stops progression from G1 to S
stop cell progression from G2 to M
CHK1 CHK2 kinases
what is the process called when a virus ‘borrows’ functional protein from another to become active for ex
hep D
complementation
what causes influenza pandemics
reassortment genetic shif t
which cancer in the lungs is assoc with PTHrp
squamous cell … central
post operative… diaphragm high and incrase lucency
atelectasis
common complication post surgery
how does tamoxifen inhibit bone loss
inhibits osteoclasts
hyperstimulation of ovaries can be seen with whch drug
clomiphene
African American woman … ACE elevated what is the diagnosis
sarcoidosis
pt has sarcoidosis … gets her treatment and then presents with certain symptoms due to overdose
cushing … due to treatment with steroids
mechanism of acetazolamide
decrease H+ secretion in proximal tubule
strept pneumo vaccine before 65
pneumococcal polysaccharide vaccine
ppsv23
PPSV23 immune resp
not comjugated to protein so cannot be presented to T cells on MHC 2
enveloped +ve sense ss RNA virus
coronavirus common cold
non enveloped +ve sense ss RNA virus
picornavirdae P polio E echovirus aseptic meningtis R rhino C coxsackie H HAV
what are the most common chemo agents for wilms tumor
vincristine ( B tubulin prevent spindle formation)
bleomycin ( induce free radicles and cause DNA breakage)
dactinomycin ( intercalates into DNA prevent RNA synth)
