multisystem pharma

Question 1

zero order kinetics drugs

Answer 1

Phenytoin
Ethanol
Aspirin

Question 2

infusion rate formula

Answer 2

steady state conc x clearance

Question 3

pralidoxime mechanism

Answer 3

dephosphorylates acetylcholinesterase and activates it

Question 4

pyridostigmine

Answer 4

acetylcholinesterase inhibitor

Question 5

cyclosporin

Answer 5

calcineurin inhibitor… binds cyclophilin…. dec IL 2 transcription

Question 6

tacrolimus

Answer 6

binds FK506…. plrevents il2 transcription

Question 7

sorilimus

Answer 7

mTOR inhibitor

Question 8

inactivation by acetylation is reistence mechanism fro

Answer 8

aminoglycosides

Question 9

aminoglycosides mechanism

Answer 9

bacteriacidal …. inhibit formation of inititation complex

Question 10

pt presents with ringing in his ears whats the toxicity

Answer 10

aspririn …. txt is bicarbonate … alkalize the urine to easily secrete acids

Question 11

Wilson disease treatment mechanism

Answer 11

D penicillamine … chemical antagonis that binds directly to the agonis

Question 12

cutaneous flushing right after injection of a drug to treat multiresistant staph

Answer 12

vanco …. slow infusion shd fix

Question 13

direct phosphorylation of drug .. reistance mechanism

Answer 13

aminoglycosides

Question 14

modification of ribosomal binding site mechanism of resis

Answer 14

tetra, chloremphincol, macrolide

Question 15

indinavir

Answer 15

protease inhibitor.. SE include thrombocytopenia (not anemia).. git intolerance, lipodystrophy and hyperg

Question 16

ziduvudine

Answer 16

nucleoside reverse transcriptase inhibitor… bone marrow suppression

Question 17

cimetidine impotannt side effect

Answer 17

blocks CP450 …. antiandrogenic effects gynecomastia etc

Question 18

common causes of gynecomastia

Answer 18

spironolactone, digoxin, cimetidine, alcohol, estrogen,heroin, dopamine anatg, ketoconazole

Question 19

pain itching dysuria and discharge plus ulcers seen on genitals … diag txt and side effects

Answer 19

genital herpes,,,, acyclovir…. neurotixicity and renal toxicity

Question 20

tobramycin belongs to wat class

Answer 20

aminoglyhcoside

Question 21

neuraminidase inhibitors

Answer 21

oseltamivir zanamivir… inhibt release of virus cells

Question 22

neurogenic bladder txt

Answer 22

bethanacol

Question 23

atypical pneumonia treatment

Answer 23

macrolides … erythromycin

Question 24

how to fix mineral imbalance in a pt with adrenal insufficiency

Answer 24

fludrocortisone (mineralocorticoid)

Question 25

antifungal that disrupts microtubule function

Answer 25

griseofulvin

Question 26

inhibits arabinosyl transferase... disrupts mechanism of carbohydrate polymerization of cell wall

Answer 26

polymyxins

Question 27

pt under treatment for seizures.... macrocytic anemia what is the drug and deficiency

Answer 27

phenytoin... def of folic acid

Question 28

side effct of polymyxin D

Answer 28

neurotixicity … ( dizziness drowsiness confusion peripheral numbness

Question 29

how to treat SVT

Answer 29

adenosine IV

Question 30

symptoms assoc with adenosine administration

Answer 30

flushing hyhpotension chest paim

Question 31

lidocaine is indicated for what type of arrhythmia and why

Answer 31

ventricular … because it has a greater affect on inacativated sodium channels

Question 32

how can we blunt adenosine effects

Answer 32

theophylline and caffeine

Question 33

procarbazine

Answer 33

anti neoplastic agent … has MAO inhibitor activity … watch for hypertensive crises

Question 34

oseltamivir drug of choice for ? and the timeline

Answer 34

influenza …. within 48 hours

Question 35

amantadine

Answer 35

Parkinson and flu ….. side effect ataxia jitteriness and indomnia

Question 36

indinavir side ffects

Answer 36

thrombocytopenia.... kidney stones

Question 37

which HIV drug causes hypercholestrolemia

Answer 37

raltegravir

Question 38

imipenem must be administed with what for better efficacy

Answer 38

cilastatin .. inibit the enzyme in PCT

Question 39

chloroquine is ued to txt is the danferous side effect

Answer 39

malaria …. torsade point

Question 40

HIV pt .. low CD cpount … on compliant .. symptoms of numbness and tingling in leg cant urinate and cant walk properly … what is the infection and the txt

Answer 40

inf with CMV... radiculopathy an aids defining condition …. SE include leukopenia. thrombocytopenia hemolytic anemia and renal toxicity

Question 41

seven transmember domain receptors are normally G coupled

Answer 41

Gq which activeate phospholipase C

Question 42

common infections of AID patient with CD 4+ count < 100

Answer 42

aspergillus, candida and CMV

Question 43

pts with hypertensive emergency should be given what drug

Answer 43

sodium nitroprusside

Question 44

a pyrophosphate that inhibits DNA RNA polymerase

Answer 44

foscarnet

Question 45

paclitaxel mechanism

Answer 45

hyperstabilize the microtubules

Question 46

vincristine

Answer 46

polymerize microtubules... neuropathy

Question 47

vincristine

Answer 47

polymerize microtubules... neuropathy

Question 48

SLE induced by what drugs

Answer 48

sulfa, hydralazine, isoniazid, procainamide, phenytoin, etanercept

Question 49

txt of atypical pneumonia

Answer 49

macrolides

Question 50

antiviral therapy that acts on RNA viruses and plays a role in natural killer

Answer 50

interferom alpha /… SE neutropenia

Question 51

an ointment .. bactericidal … rarely used systemically due to nephrotoxicity

Answer 51

bacitracin … inhibits cell wall synthesis

Question 52

pt has otitis externa what could be the bacterial agents

Answer 52

pseudomonas and staph aureis first line txt with fluoroquinolone or polymyxin B I chose piperacillin but that doesn't cover staph aureus

Question 53

clomiphene mechanism of action

Answer 53

estrogen antagonis at the level of hypothalamus … reduces negative feeeeedback to hypothalamus … increase GNRH … increase LH .. increase testosterone