resp onc 2 Flashcards
pt with LHF … increased diastolic pressure
what happens to elastic recoil
increase recoil … decrease compliance
what does spontaneous pneumothorax do to all the lung capacities
DECREASE
what is vital capacity
total amount of air that can be exhaled
inc FRC inc TLC but decreased vital capacity
obstructive disease
biopsy of spleen reveals lymph node like structure with abnormal germinal centers ….+ve for CD 20 and BCL2
follicular lymphoma … t (14,18
overexpression of cyclin D
Mantle cell lymphoma … t (11,14)
B cell neoplasm …. overproduction of igM…. nose bleeds due to damaged vessels … igM increases viscocity of blood
waldernstrom macroglobulenemia
protein A binds Fc portion
staph aureus
moleculre mimicry caused by which virulence factor
M protein
zileuton mechanism
bock conversion of arachidonic acid to lipoxygenase 5
moteleukast
inhibit the leukotriene receptors
what is rb gene and how does it play a role in cancer devp
it is a tumor suppressor gene that normally inactivates E2F
pancreatic cancer gene mutation
p16
burning feet syndrome caused by which def
pantothenic acid b5
which synthetic steroid requires bioactivation
prednison
chemotherapy regimen for hodgkins
Adriamycine (doxorubicin)
Bleomycine
vinblastine
Dacarbazine
residents of a nursing hoime that have rhinorrhea, non productive cough, headaches, myalgias normally have what disease
influenza
late protein synthesis inhbitors
amprenavir
viral adsorption inhib
gamma globulins … increase hep A immunity
diffusion of oxygen into alveolar walls decreases in what condition
emphysema due to smoking , emphysema damages the alveolar walls
decreased ability of hb to bind oxygen
sickle cell anemia of CO poisoning
multiple nodular opacities that appear scattered throughout the peripheral lmph nodes and upper lobe
silicosis
exposure to rock mineral sand and smoking
mucous gland hypertrophy and hyperplasisa seen in
bronchitis
irregular non septate hyphae branching at 100 deg
mucor
BRAF oncogene mutation
papillary thyroid carcinoma
RAS
follicular thyroid carcinoma
what pattern of lung disease is obesity assoc with
restrictive pattern due to the increased inward recoil of chest wall
kidney transplant pt .. fever cough and acid fast stain shows long branching filaments
nocardia … txt with sulfonamides
new bord with ARDS what do u do
treat with exogenous phosphatidylcholine although it does NOT reverse the pathology
a child from congo … history of fever ,,, no vaccination ,,, right hip is externally rotated …inc WBC count….. aspiration of joint shows organism that grows on choclte agar not blood agar …. wht is the virulence factor of this organism
a capsule
H. influenza
signs of septic arthritis
which cephalosporin has activity against pseudomonas
ceftazidime
child irritable watery diarrhea and fever …. N myc oncogene
neuroblastoma … adrenal glands
mutations of c kit gene
gastro stromal tumors
C myc mutations
Burkitt lymphoma t 8 14
primary prevention
interventions to prevent onset of the disease
secondary prevention
identifying the asymptomatic disease in pt and stopping its progression
tertiary prev
diagnosing the disease and treating it to reduce morbidity
what is the function of surfactant
decrease alveolar surface tension and increase compliance
mechanism cross link DNA and causes peripheral neuropathy
cisplatin
increase number of mucous plugs and smooth muscle cell prolif
in ashma patients
desquamation of resp epithelium
bronciectasis
a drug that breaks DNA strands through free radical formation
bleomycin and causes p fibrosis
pt presents with classic symp of influenza and gets treated with oseltamivir … starts feeling better but now has fever and coughing up green sputum… xray confirms lower lobe consolidation
this is bacterial pneumo after influenza inf
can be strept pyogenes (M protein), staph aureus, h influenza (capsule), strept pneumo (igA protease)
