Reproductive Flashcards
Mutation of Sonic Hedgehog gene causes
Holoprosencephaly
Wnt-7 gene necessary for
Proper organization along dorsal-ventral axis
ACE i teratogen
Renal damage
Alkylating agents teratogen
Absence of digits
AG teratogen
CN 8 toxicity
Carbamazepine teratogen (4)
- Neural tube defects
- Craniofacial defects
- Fingernail hypoplasia
- Developmental delay
Lithium teratogen
Ebstein anomaly (atrialized right ventricle)
Phenytoin teratogen (5)
Fetal hydantoin syndrome:
- microcephaly
- Dysmorphic craniofacial features
- Hypoplastic nails and distal phalanges
- Cardiac defect
- Intellectual disability
Tetracyclines teratogen
Discolored teeth
Thalidomide teratogen
Limb defects
Valproate teratogen
Neural tube defects
Warfarn teratogen (4)
- Bone deformities
- Fetal hemorrhage
- Abortion
- Ophthalmologic abnormalities
Cocaine teratogen (3)
- Abnormal fetal growth
- Fetal addiction
- Placenta abruption
First part of aortic arch develops into
Maxillary artery
Second part of aortic arch develops into
Stapedial artery
Third part of aortic arch develops into (2)
- Common cartoid
- Internal carotid
Left forth aortic arch develops into
Aortic arch
Right forth aortic arch develops into
Proximal part of right subclavian
What cartilage is derived from 1st brachial arch (5)
- Meckel
- Mandible
- Malleus
- Incus
- Spheno-mandibular ligament
What muscles derived from 1st brachial arch (5)
- Muscles of mastication
- Mylohyoid
- anterior belly of digastic
- Tensor tympani
- Tensor veli palatini
What Nerve is derived from 1st brachial arch
CN 52 and53
Treacher collins syndrome is
1st-brachial arch neural crest fails to migrate causing mandibular hypoplasia and facial abnormalities
Cartilage of 2nd brachial arch (4)
- Stapes
- Syloid process
- Lesser horn of hyoid
- Sylohyoid
Muscles of 2nd brachial arch (3)
- Stapedius
- Sylohyoid
- Platysma
Nerve of 2nd brachial arch
CN7
Congenital phayngo-cutaneous fistula is
Persistance of cleft and pouch due to 2nd brachial arch malformation
Muscles of 3rd brachial arch
Stylopharyngeus
Nerve of 3rd brachial arch
CN9
Ear, Tonsils, Bottom-to-top
Derivatives of Brachial pouch
- Ear: 1st
- Tonsils: 2nd
- Bottom (inferior parathyroid): 3rd
- To (thymus): 3rd
- Top (superior parathyroid): 4th
Infundibulopelvic ligament (Suspensory ligament of the ovaries) connects
Ovaries to lateral pelvic wall
Cardinal ligament connects
Cervix to side wall of pelivs
Round ligament of uterus connects
Uterine fundus to labia majora
Broad ligament connects
Uterus, fallopian tubes and ovaries to pelvic side wall
Broad ligament contains (3)
- Ovaries
- Fallopian tubes
- Round ligament of uterus
Sperm pathway
SEVENUP
- Seminiferous tubules
- Epididymis
- Vas deferens
- Ejaculatory duct
- NOTHING
- Urethra
- Penis
Estriol source
Placenta
Estrone source
Adipose tissue
LH in females acts on
Theca cells to converte cholesterol to andrones
FSH in females acts on
Granulosa cells to converte Andrones to Estrogen
Source of progesterone (4)
- Corpus luteum
- Placenta
- Adrenal cortex
- Testes
Defective androgen receptor lab results
Increase testosterone and increase LH
Testosterone-secreting tumor or exogenous steroids lab results
Increase testosterone
Decrease LH
Primary hyogonadism lab results
Decrease Testosterone
Increas LH
Hypogonadotropic hypogonadism lab results
Decrease testosterone and LH
Severe increase in hCG seen in what type of mole
Complete
Fetal parts are seen in what type of mole
Partial
Placenta accreta is
Placenta attaches to myometrium
Placenta increta is
Placenta penetrates into myometrium
Placent percreta is
Placenta penetrates through the myometrium and into uterine serosa
Polyhdramnios associted with (4)
- Fetal malformations:
- Esophagel/dudodenal atresia
- anencephaly
- Inability to swallow amniotic fluid
- Maternal diabetes
- Fetal anemia
- Multiple gestations
Oligohydramnios associated with (4)
- Placental insufficiency
- Bilateral renal agenesis
- Posterior urtheral valves (in males)
- Cant excrete urine
Oligohydramnios can cause
Potter sequence
Endometritis associated with
Retained products of conception following delivery
Endometritis treatment
Gentamicin and clindamycin with or without ampicillin
Endometrioma is
Mass arising from growth of ectopic endometrial tissue
Endometrioma presents with (3)
- Pelvic pain
- Dysmenorrhea
- Dyspareunia
Brenner tumor on H&E
Coffee bean nuclei
Call-Exner bodies seen in
Granulosa cell tumor
What ovarian neoplasm has Psammoma bodies
Serous cystadenocarcinoma
Dysgerminoma tumor markers
hCG
LDH
Schiller-Duval bodies seen in
Yolk sac (endodermal sinus) tumor
Yolk sac tumor marker
AFP
Tumors found in the stroma of breat (2)
- Fibroadenoma
- Phyllodes tumor
Breast pathology that occur in major duct (3)
- Fibrocystic change
- DCIS
- Invasive ductal carcinoma
Benign tumor in lactiferous ducts of breast
Intraductal papilloma
Treat acute mastitis with
Dicloxacillin
Some Dope Drugs Easily Create Awkward Hairy DD Knockers reason for Gynecomastia
- Spironolactone
- Dope
- Digitalis
- Estrogen
- Cimetidine
- Alcohol
- Heroin
- Dopamine
- D2 antagonist
- Ketoconazole
Reinke crystals seen in
Leydig cells tumor
Leuprolide MOA (2)
- GnRH analog with agonist properties when used in pulsatile fashion
- GnRH analog with antagonist properties when used in continuous fashion
Clomiphene MOA
Antagonist at estrogen receptors in hypothalamus reventing normal feedback inhibition and increase release of LH and FSH from pituitary
Clomiphene used for
Treat infertility due to anovulation
Tamoxifen MOA (2)
- Estrogen receptor antagonist on breast tissue
- Estrogen receptor agonist on Uterus and Bone
Raloxifene MOA (2)
- Estorgen receptor agonist on bone
- Estrogen receptor antagonist at uterus
Aromatase inhibitors used in postmenopausal women with breast cancer (2)
- Anastrozole
- Exemestane
Mifepristone MOA
Competitive inhibitor of pregestins at progesterone receptors
Mifepristone used for
Termination of pregnancy
Mifepristone is administered with
Misoprostol (PGE1)
Terbutaline MOA
β2-agonist that relaxes the uterus used to decrease contraction frequency
Danazol MOA
Synthetic androgen that acts as partial agonist at androgen receptors
Danazol used for
Endometriosis and hereditary angioedema
Danazol toxicity (7)
- Weight gain
- Edema
- Acne
- Hirsutism
- Masculinization
- Decrease HDL
- Hepatotoxicity
Finasteride MOA
5α-reductase inhibitor
Flutamide MOA
Nonsteroidal competitive inhibitor of androgens used in prostate carcinoma