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Immuno Flashcards

1
Q

Secreted proteins in Innate immunity

A
  1. Lysozyme
  2. Complement
  3. CRP
  4. Defensins
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2
Q

HLA-A3 disease

A

Hemochromatosis

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3
Q

HLA-B27 Diseases

PAIR

A
  • Psoriatic arthritis
  • Ankylosing spondylitis
  • Inflammatory bowel disease arthritis
  • Reactive artheritis (Reiter syndrome)
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4
Q

HLA-DQ2/DQ8 disease

A

Celiac

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5
Q

HLA-DR2 disease

A
  1. MS
  2. Hay fever
  3. Goodpasture
  4. SLE
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6
Q

HLA-DR3 disease

A
  1. DM type 1
  2. SLE
  3. Graves
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7
Q

HLA-DR4 disease

A

RA

DM type 1

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8
Q

HLA-DR5 disease

A

Pernicious anemia: B12 deficiency

Hashimoto

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9
Q

SLE HLA

A

DR2

DR3

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10
Q

DM type 1 HLA

A

DR3

DR4

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11
Q

NK cells enhanced by

A
  • IL-2
  • IL-12
  • IFN-β
  • IFN-α
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12
Q

Acute-phase reactants induced by

A
  1. IL-6
  2. IL-1
  3. TNF-α
  4. IFN-γ
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13
Q

C1 esterase inhibitor deficiency causes

A

Hereditary angioedema

ACE inhibitors are contraindicated

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14
Q

DAF deficiency causes

A

Complement-mediated lysis of RBC

Paroxysmal nocturnal hemoglobinuria

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15
Q

Hot T-Bone stEAK

A
  1. IL-1: fever (hot)
  2. IL-2: stimulates T cells
  3. IL-3: stimulates Bone marrow
  4. IL-4: stimulates IgE production
  5. IL-5: stimulates IgA production
  6. IL-6: stimulates aKute-phase protein
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16
Q

Cytokines secreated by macrophages

A
  1. IL-1
  2. IL-6
  3. IL-8
  4. IL-12
  5. TNF-α
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17
Q

IL-12 induces

A

Differentiation of T cells into Th1 cells

Activates NK cells

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18
Q

TNF-α action

A
  1. Mediates septic shock
  2. Activates endothelium
  3. Causes leukocyte recruitment
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19
Q

Cytokines secreted by T cells

A

IL-2

IL-3

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20
Q

Th1 cells secrete

A

IFN-γ

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21
Q

Myasthenia autoAB

A

Anti-ACh receptor

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22
Q

Goodpasture AutoAB

A

Anti-BM

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23
Q

SLE AutoAB

A

Anti-cardiolipin

Anti-dsDNA

anti-Smith

ANA

24
Q

Type 1 DM AutoAB

A

Anti-glutamate decarboxylase

25
Q

Bruton agammaglobulinemia defect

A

X-linked defectin BTK leading to no B cell maturation

26
Q

T-cell disorders (4)

A
  1. DiGeorge
  2. IL-12 receptor deficiency
  3. Job syndrome (Hyper-IgE)
  4. Chronic mucocutaneous candidiasis
27
Q

IL-12 receptor deficiency is

A

AR causes decrease Th1 response

28
Q

Job syndrome aka

A

AD hyper-IgE syndrome

29
Q

Job syndrome is FATED

A
  1. Coarse Face
  2. Abscess due to Staph
  3. Primary Teeth retained
  4. IgE increased
  5. Dermatologic
30
Q

Job syndrome due to

A

STAT3 mutation causing TH17 deficiency

31
Q

Ataxia-telangiectasia is a defect in

A

ATM leading to DNA double strand break and causes cell cycle to arrest

32
Q

Ataxia-telangiectasia triad

A

Ataxia

Spider Angioma

IgA deficiency

33
Q

Wiskott-Aldrich syndrome is a mutation

A

X-linked recessive mutation in WAS gene leading to T cells unable to reorganize actin cytoskeleton

34
Q

Wiskott-Aldrich is WATER

A
  1. Wiskott-Aldrich
  2. Thrombocytopenic purpura
  3. Eczema
  4. Recurrent
35
Q

Chédiak-Higashi defect is

A

AR defect in Lysosomal trafficking regulator gene causing microtubule dysfunction in phagosome-lysosome fusion

36
Q

Chédiak-Higashi syndrome clinical

A
  1. Recurrent pyogenic infections
  2. Albinism
  3. Peripheral neuropathy
  4. Progressive neurodegeneration
37
Q

Cyclosporine MOA

A
  1. Calcineurin inhibitor
  2. Binds cyclophilin
  3. Bloks T-cell activation by preventing IL-2 transcription
38
Q

Cyclosporine toxicity (7)

A
  1. Nephrotoxic
  2. HT
  3. Hyperlipidemia
  4. Hyperglycemia
  5. Tremor
  6. Hirsutism
  7. Gingival hyperplasia
39
Q

Tacrolimus MOA

A
  1. Calcineurin inhibitor
  2. Binds FK506 binding protein
  3. Blocks T cell activation by preventing IL-2 transcription
40
Q

Sirolimus aka

41
Q

Sirolimus MOA

A
  1. mTOR inhibitor
  2. Blocks T cell activation and B cell differention by preventing IL-2 signal tranduction
42
Q

What immunosuppressant used in Kidney transplant

43
Q

Basilizimab is

A

Monoclonal AB that blocks IL-2R

44
Q

Azathioprine MOA

A
  1. Precursor of 6-MP
  2. Inhibits lymphocyte proliferation by blocking nucleotide synthesis
45
Q

AB used for cancer therapy (5)

A
  1. Alemtuzumab
  2. Bevacizumab
  3. Cetuximab
  4. Rituximab
  5. Trastuzumab
46
Q

Alemtuzumab targets

A

CD52 used for CLL

47
Q

Bevacizumab targets

A

VEGF used for colorectal and renal cell carcinoma

48
Q

Cetuximab target

A

EGFR for Stage 4 colorectal cancer and Head and neck cancer

49
Q

Rituximab target

A

CD20 for B-cell lymphoma, RA and ITP

50
Q

Trastuzumab target

51
Q

AB used for Autoimmune diease (3)

A
  1. Infliximab
  2. Adalimumab
  3. Natalizumab
52
Q

What antibody targets TNF-α in RA

A
  1. Infliximab
  2. Adalimumab
53
Q

Natalizumab targets

A

α4-integrin used for multiple sclerosis and Crohns

54
Q

Abciximab target

A

Glycoprotein 2b/3a

55
Q

Denosumab targets

A

RANKL in osteoporosis

56
Q

Omalizumab targets

A

IgE in asthma

57
Q

Palivizumab target

A

RSV F protein

First Aid (16 decks)

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