Reproduction - male anatomy/spermatogenesis Flashcards
What are testes?
Secrete male sex hormones and produce male gametes and sperm
Pass through inguinal ring
What muscles are important for testes thermoregulation?
Dartos and cremaster muscles
what are the structures within the testes and joining to body?
Seminiferous tubules
Rete testes
Efferent ductules
Epididymus ( head/caput, body/corpus, tail/cauda)
Spermatic cord (vas deferens, pampiniform plexus, cremaster muscle)
What are within/between seminiferous tubules?
In the tubules: sertoli cells
Between tubules: Leydig cells
What do sertoli cells do?
Control spermatogenesis by transferring developmental proteins to spermatocytes, they also remove material from elongating spermatids
Joined by gap junctions
What do leydig cells do?
These produce testosterone and stimulate sertoli cells
What is the pathway for testosterone production?
Leydig cell
Cholesterol>Pregnenolone>Testosterone
Sertoli cell
Testosterone?Dihydrotestosterone
What controls testosterone production?
GnRH (hypothalamus)
LH/FSH (anterior pituitary)
LH > leydig cells
FSH > sertoli cells > receptors to be responsive to testosterone
What happens if the pituitary gland is removed?
Testes shrink and no spermatogenesis
Leydig cells deteriorate and little/no testosterone output.
What happens if the testes are removed?
Complete stop of testosterone production and helps control behaviour
What is spermatogenesis?
The production of sperm
How does spermatogenesis occur?
- Spermatogonal stem cells develop and proliferate via mitosis (diploid)
- Spermatocytes undergo meiotic division and become genetically different spermatids
- Spermatids are packaged up and elongated to become spermatozoa via cytodifferentation
Where is spermatozoa concentrated and matured?
In the retis testis and mature in the epididymus
What happens in the caput/head of the epididymus?
The fluid from the sertoli cells is resporbed and the sperm is concentrated
The muscles propel the sperm forward as is not motile or fertile
What happens in the corpus/body of the epididymus ?
The sperm matures and the environment is modified:
- loss of cytoplasmic droplet and nuclear chromatin condenses via disulphide bridges
-surface glycoproteins are added and the lipid composition of the membrane changes to fatty acids
-Metabolic activity is depressed to become dependent on fructose and prolong cell life
-cAMP content of tail increases to aquire motility