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VSCI200 NSF > repro pharm > Flashcards

repro pharm Flashcards

1
Q

name a synth progesterone used to chemically castrate hypersexual dogs

A

delmadinone

tardak

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2
Q

name a progesterone r blocker

A

Aglepristone

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3
Q

name a syn progesterone used to sync horses and pigs

A

altrenogestt/regumate

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4
Q

what are the adverse effect of prog tx?

A 
endo hyperplasia
endometrirtis
pyometria
inhib id ACTH
behavoural changes
DM
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5
Q

what are the efffects of prog

A

inc mammary growth
inc luteal phase
no oxytocin R
anabolic effects

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6
Q

where secretes prog

A

CL
placenta
adrenal cortex

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7
Q

what is the most potent endog oestrogen

A

oestradiol

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8
Q

what is a oestrog synth used to treat spay-related incontinence

A

oestriol

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9
Q

where is oestrogen secreted from

A

ovaries (granulosa cells)
placenta
testes (sertoli)
adrenal cortex

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10
Q

name 2 androgen inhibitors

A

finasteride

osaterone

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11
Q

what are the adverse effects of androgens (testosterone basically..)

A 
infert
oligospermia
perineal hernia
butch females
hepatox
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12
Q

name a synth androgen which is a strong anobolic steroid

A

nandrolone

used in renal failure of cats

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13
Q

name a synth androgen

A

danazol

immune mediated disease

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14
Q

where are androgen released from

A

zona reticularis

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15
Q

where is prog secreted from?

A

CL

Placenta

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16
Q

where is test secreted from

A

ledig cells

theca cells

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17
Q

what is the effect of oxytocin?

A

inc myometrial contraction
milk let down
may cause dystocia

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18
Q

when are oxytocin R availbale

A

high oest

low prog

19
Q

name a prolactin inhib

A

Cabergoline (galastop)

induce oestrous and tx false preg

20
Q

why can oxytocin and ADH be released together

A

release of both is controlled by same nuclei and from the post pit

21
Q

what stimulates milk let down

A

oxytocin release which is stim by tactile, visual and auditory stimuli

22
Q

lactogenesis is

A

endocrine control of birth and let down

23
Q

galactoopeisis s

A

production of milk

24
Q

what need to happen for galactopoeisis to contineu

A

suckling

25
Q

name synth GnRH

A

gonadorelin

26
Q

name a GnRH agonist used in mares

A

deslorelin

27
Q

what can GnRH intervention do

A 
manipulate follicular waves
induce ovul
synch oestrous
control luteal phase
stim ovarian activity
advance oestrous
induce parturition
misalliance
suppress repr (cat, dog and horse)
28
Q

what stimulates puberty

A

GnRH pulse gen inc freq

29
Q

how can you induce superovulation?

A

FSH inj (procine extract)

30
Q

when do endometrial cups appear?

A

d40-120 of preg

31
Q

what do endometrial cups produce?

A

eCG

32
Q

why would an injection of hCG be useful in suspect cryptorchid? (hint: it has a LH-lik effect)

A

will cause a rise of testosterone in the blood

33
Q

what type of effect does eCG have FSH-like or LH like?

A

FSH

34
Q

what is apotential SE of GnRH inj?

A

anaphylaxis, interspecies samples

35
Q

name a recomb PGF2a

A

Dinoprost

36
Q

name a synth PGF2a

A

colprostenol

37
Q

what is the action of PG on the luteal phase

A

shortens it

38
Q

how can GnRH be used to effect the luteal phase

A

it can tighten the timing of ovulation

as whilst PG is causing luteolysis, stim GnRH causes FSH and follicular dev therefore ovulation

39
Q

clenbuterol relaxes smooth muscle, what adreno-R does it agonise?

A

B2

used to reduce myometrial contractions and dilate airways

40
Q

when would a reduction in myometrial contraction be useful?

A

dystocia and malpresentation of calves

41
Q

why would melatonin help oestrous synch

A

will inc or dec GnRH in seasonal breeders, may be able to advance breeding season - THOUGH only if everything else is 100% fine

42
Q

at term how can parturition be induced>

A

g-corticoids

PGs

43
Q

what animal can be induced by oxytocin

A

mares only

VSCI200 NSF (25 decks)

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