repro pharm Flashcards
name a synth progesterone used to chemically castrate hypersexual dogs
delmadinone
tardak
name a progesterone r blocker
Aglepristone
name a syn progesterone used to sync horses and pigs
altrenogestt/regumate
what are the adverse effect of prog tx?
endo hyperplasia endometrirtis pyometria inhib id ACTH behavoural changes DM
what are the efffects of prog
inc mammary growth
inc luteal phase
no oxytocin R
anabolic effects
where secretes prog
CL
placenta
adrenal cortex
what is the most potent endog oestrogen
oestradiol
what is a oestrog synth used to treat spay-related incontinence
oestriol
where is oestrogen secreted from
ovaries (granulosa cells)
placenta
testes (sertoli)
adrenal cortex
name 2 androgen inhibitors
finasteride
osaterone
what are the adverse effects of androgens (testosterone basically..)
infert oligospermia perineal hernia butch females hepatox
name a synth androgen which is a strong anobolic steroid
nandrolone
used in renal failure of cats
name a synth androgen
danazol
immune mediated disease
where are androgen released from
zona reticularis
where is prog secreted from?
CL
Placenta
where is test secreted from
ledig cells
theca cells
what is the effect of oxytocin?
inc myometrial contraction
milk let down
may cause dystocia
when are oxytocin R availbale
high oest
low prog
name a prolactin inhib
Cabergoline (galastop)
induce oestrous and tx false preg
why can oxytocin and ADH be released together
release of both is controlled by same nuclei and from the post pit
what stimulates milk let down
oxytocin release which is stim by tactile, visual and auditory stimuli
lactogenesis is
endocrine control of birth and let down
galactoopeisis s
production of milk
what need to happen for galactopoeisis to contineu
suckling
name synth GnRH
gonadorelin
name a GnRH agonist used in mares
deslorelin
what can GnRH intervention do
manipulate follicular waves induce ovul synch oestrous control luteal phase stim ovarian activity advance oestrous induce parturition misalliance suppress repr (cat, dog and horse)
what stimulates puberty
GnRH pulse gen inc freq
how can you induce superovulation?
FSH inj (procine extract)
when do endometrial cups appear?
d40-120 of preg
what do endometrial cups produce?
eCG
why would an injection of hCG be useful in suspect cryptorchid? (hint: it has a LH-lik effect)
will cause a rise of testosterone in the blood
what type of effect does eCG have FSH-like or LH like?
FSH
what is apotential SE of GnRH inj?
anaphylaxis, interspecies samples
name a recomb PGF2a
Dinoprost
name a synth PGF2a
colprostenol
what is the action of PG on the luteal phase
shortens it
how can GnRH be used to effect the luteal phase
it can tighten the timing of ovulation
as whilst PG is causing luteolysis, stim GnRH causes FSH and follicular dev therefore ovulation
clenbuterol relaxes smooth muscle, what adreno-R does it agonise?
B2
used to reduce myometrial contractions and dilate airways
when would a reduction in myometrial contraction be useful?
dystocia and malpresentation of calves
why would melatonin help oestrous synch
will inc or dec GnRH in seasonal breeders, may be able to advance breeding season - THOUGH only if everything else is 100% fine
at term how can parturition be induced>
g-corticoids
PGs
what animal can be induced by oxytocin
mares only
