Repro Drugs

Question 1

Leuprolide given in continuous fashion for what conditions?

Answer 1

downregulates GnRH– used for prostate cancer; uterine fibroids; precocious puberty

Question 2

Ketoconazole in female repro?

Answer 2

Inhibits steroid synthesis by blocks desmolase–Used in PCOS

Question 3

Spironolactone?

Answer 3

inhibits steroid binding– used in pcos

Question 4

Norethindrone?

Answer 4

Progestin only– lowers midcycle lh and fsh– may cause ectopic pregnancy

Question 5

Clomiphene ?

Answer 5

Partial agonist at estrogen receptor– prevents feedback inhibition and increased release of LH and FSH –>ovulation

Question 6

Used in infertility– partial agonist?

Answer 6

Clomiphene

Question 7

Aromatase inhibitor used in postmenopausal women with breast cancer?

Answer 7

Anastraozole