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Elliot Step 1 > Random 2 > Flashcards

Random 2 Flashcards

1
Q

MCC tumor of adrenal medulla in children?

A

Neuroblastoma

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2
Q

Anterior pit derived from?

Post pit derived from

A

ant=rathkes pouch– oral ectoderm

Post=neuroectoderm

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3
Q

Insulin dependent channel?

A

glut 4– adipose tissue and skeletal muscle

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4
Q

hormone that stimulates prolactin release?

A

TRH

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5
Q

17 alpha hydroxylase deficiency– what will XX phenotype look like?

A

Externally phenotypic female with normal internal sex organs, lacks secondary sexual characteristics

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6
Q

17 alpha hydroxylase deficiency– what will XY phenotype show?

A

ambiguous genitalia; undescended testes

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7
Q

How does cortisol maintain blood pressure?

A

Increases alpha 1 receptors on arterioles–>inc sensitivity to NE and Epi

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8
Q

IP3 signaling pathway?

A

GGOAT GnRH; GHRH; Oxytocin; ADh, TRH

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9
Q

Vit D and aldosterone signaling pathway?

A

Steroid receptor

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10
Q

Thyroid hormone leads to increase of this receptor?

A

Beta One receptor in heart

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11
Q

Increases beta one receptor in heart?/

A

TH

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12
Q

Describe negative feedback of T3

A

feeds back on anterior pituitary to decrease its sensitivity to TRH

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13
Q

3 things that increase thryoid binding globulin?

A

Pregnancy, OCP (sort of the same thing) and Hepatic failure

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14
Q

Elevated HVA; tumor

A

Neuroblastoma

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15
Q

Myxedema vs pretibial myxedema

A

facial/periorbital myxedema is HYPOTHYROIDISM

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16
Q

histology of hashimotos

A

Lymphocytic infiltrate with germinal centers– CELL MEDIATED IMMUNE RESPONSE

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17
Q

HLA DR 5?

A

Hashimotos– 5 dollars for chinese chicken

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18
Q

Protuberant tongue; portruding umbilicus

A

cretinism

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19
Q

Riedels thryoditis– thyroid replaced by?

A

fibrous tissue

20
Q

thyroid cancer– capsular infiltration?

A

follicular carcinoma

21
Q

sheets of cells in amyloid stroma

A

Medullary carcinoma

22
Q

What will you see in urine in primary hyperparathyroidism?

A

cAMP– blood will show high alk phos

23
Q

Kidney stones, many fractures, constipation, psych shit

A

primary hyperparathyroidism

24
Q

Hight PTH; hypocalcemia; shortened 4th and 5th digits; short stature

A

pseudohypoparathyroidism

25
Q

two treatments for pituitary adenoma

A

cabergoline and bromocriptine

26
Q

3 drugs to treat nephrogenic DI?

A

HCTZ; indomethacin; amiloride

27
Q

empty sella syndrome is common in?

A

obese women

28
Q

HLA dr3 and dr4

A

type 1 diabetes mellitus

29
Q

difference in histology of dm1 and dm2

A

dm1=leukocytic infiltrate

dm2=amyloid deposit

30
Q

describe rhizopus

A

Broad, nonseptae hyphae– branch at 90 angles

31
Q

carcinoid syndrome can result in which vitamin deficiency?

A

Niacin– remember that niacin is derived from tryptophan and carcinoid syndrome has increased serotonin which is also derived from tryptophan–>dec in tryptophan–>dec in niacin which can cause pellagra

32
Q

MEN1 often present with?

A

kidney stones and stmoach cancers

33
Q

DDX for disulfiram like effects?

A

Sulfonylureas; metronidazole; griseofulvin

34
Q

How do DPP-4 inhibitors work?

A

GLP1 is inactivated by DPP4 (DPP4= gliptins)

glp1 analogs= exenatide and liraglutide

35
Q

Steroid receptor pathway

A

VETTT CAP

Vitamin D; estrogen; T3 T4; testosterone; cortisol; aldosterone progesterone

36
Q

Post pituitary derived from?

A

Neural tube (ectoderm)

37
Q

GI tract derived from?

CV derived from?

A

Endoderm

Mesoderm

38
Q

Besides ataxia and telangiectasia– what else can be seen in an AT patient

A

humoral and cellular immune dysfunction

39
Q

this murmur is heard best with the patient leaning forward

A

Aortic regurg

40
Q

Daytime and nighttime treatment for narcolepsy?

A

Modafinil and amphetamines during day

Sodium oxybate at night

41
Q

Target cells?

A

HALT!!!!! HbC, asplenia, liver disease, thalassemi

42
Q

Basophilic stippling/

A

TAiL

Thalassemia, Anemia of chronic disease, lead poisoning

43
Q

Crew cut appearance on xray?

A

Beta thal major

44
Q

Defect in sideroblastic anemia?

A

ALA synthase – can be caused by alcohol lead and isoniazid– treat with pyridoxine!!!

45
Q

Treat sideroblastic anemia with?

A

pyridoxine

Elliot Step 1 (32 decks)

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