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Elliot Step 1 > Psych Drugs > Flashcards

Psych Drugs Flashcards

1
Q

Drug for alchohol withdrawal?

A

Benzodiazepines

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2
Q

Drug for anxiety?

A

SSRI, SNRI, buspirone

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3
Q

ADHD drug?

A

Methylphenidate, amphetamines

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4
Q

Bipolar drugs?

A

Lithium; valproid acid; carbamazepine; atypical antipsychotics

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5
Q

Bulimia drug?

A

SSRI

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6
Q

Depression with insomnia?

A

Mirtazapine

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7
Q

OCD?

A

SSRI and clomipramine

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8
Q

Panic disorder drugs?

A

SSRI, Vanlafaxine, benzodiazepines

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9
Q

PTSD drugs?

A

SSRI

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10
Q

Tourette’s drugs?

A

antipsychotics (halo; risperidone)

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11
Q

MOA of typical antipsychotics?

A

Block dopamine D2 receptors leading to an increase in cAMP

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12
Q

Typical antipsychotics with extrapyramidal symptoms?

A

Trifluoperazine, fluphenazine, haloperidol (Try to Fly High)

High potency

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13
Q

Low potency typical antipsychotics (anticholinergic; antihistamine; alpha 1 blockade)

A

Chlorpromazine, Thioridazine (Cheating Thieves are low)

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14
Q

Patient presents with myoglobinuria; autonomic instability, hyperpyrexia, rigidity– What is this called? What is treatment?

A

Neuroleptic malignant syndrome– treate with dantrolene (muscle relaxant) and D2 agonists (bromocriptine)

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15
Q

Side effects of typical antipsychotics?

A

Highly lipid soluble (removed slowly)
Extrapyramidal (eg dyskinesias)
Dopamine block (hyperprolactinemia)
Muscarininc and alpha 1 and histamine blockade

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16
Q

Stereotypic oral facial movements as a result of long term antipsychotic use?

A

Tardive dyskinesia– usually irreversible

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17
Q

Fever; encephalopathy; unstable vitals, rigidity of muscles, elevated enzymes?

A

Neuroleptic malignant syndrome (FEVER)

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18
Q

Typical antipsychotics?

A

Haloperidol and “azines” (eg. fluphenazine, thioridazine, chlorpromazine, trifluoperazine)

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19
Q

Atypical antipsychotics?

A

It’s Atypical for OLd CLOSets to QUIETly RISPER from A to Z (Olanzapine, clozapine, Quietiapine, Risperidone, Aripiprazole, Ziprasidone)

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20
Q

Least sedating atypical antipsychotic and why?

A

Aripiprazole because it’s a partial agonist and antagonist

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21
Q

Atypical antipsychotic side effect of agranulocytosis?

A

Clozapine

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22
Q

Side effect of clozapine?

A

Agranulocytosis– requires weekly WBC AND seizures

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23
Q

Atypicals that cause weight gain?

A

Olanzapine and clozapine (If i gain weight, I can’t be on the OC)

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24
Q

Atypical that prolongs QT interval?

A

Ziprasidone

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25
Q

Uses of Lithium?

A

SIADH and bipolar

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26
Q

Side effects of lithium?

A

LMNOP: Movement (tremor),
Nephrogenic diabetes insipidus
hypOthyroidism
Pregnancy problems

Can also cause heart block

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27
Q

Blood work that must be checked in a patient on Lithium?

A

Thyroid levels

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28
Q

Fetal defects associated with lithium?

A

Cardiac defects include Ebstein anomaly and malformation of great vessels.

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29
Q

Lithium is excreted by?

A

Kidneys– reabsorbed at proximal convoluted tubules following Na reabsorption

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30
Q

Stimulates 5HT1a– used for GAD?

A

Buspirone– takes 1-2 weeks to take effect

31
Q

What should you tell a patient when starting them on Buspirone?

A

Takes 1-2 weeks to take effect

32
Q

SSRIs are not used in which two diseases?

A

Schizophrenia and Bipolar

33
Q

Methylphenidate?

A

CNS stimulant (ritalin) increases catacholamines at synaptic cleft– especially NE and dopamine

34
Q

Treatment of ADHD?

A

end in “amphetamine” and Methylphenidate

35
Q

Work by increasing catecholamines at synaptic cleft?

A

CNS stimulants (amphetamines and methylphenidate)– used for narcolepsy and appetite control

36
Q

4 hr actue muscle spasm, stiffness

A

dystonia (EPS side effect of typicals)

37
Q

4 day restlessness?

A

Akathisia (SE of typicals)

38
Q

4 week parkinson like symptoms?

A

Bradykinesia (side effect of typicals)

39
Q

Typicals that cause deposits in eye?

A

Chlorpromazine goes to cornea

Thioridazine goes to reTina

40
Q

Deposits in retina?

A

thioridazine

41
Q

Deposits in cornea?

A

Chlorpromazine

42
Q

SSRIs?

A

Fluoxetine (Prozac); Paroxetine (Paxol); Sertraline (zoloft); Citalopram— FLashbacks PARalyze SEnior CITizens

43
Q

Fluoxetine?

A

SSRI

44
Q

Paroxetine?

A

SSRI

45
Q

Citalopram?

A

SSRI

46
Q

Sertraline?

A

SSRI

47
Q

Pt. presents with fever, confusion, twitching of muscles, flushing, and diarrhea after starting a medication for depression. How should this patient be treated?

A

Pt. presenting with Serotonin syndrome— treat with cyproheptadine which is a seretonin antagonist

48
Q

Cyproheptadine?

A

Seretonin antagonist used to treat serotonin syndrome

49
Q

Venlafaxine?

A

SNRI– inhibit serotonin and NE reuptake

50
Q

Duloxetine?

A

SNRI– inhibit serotonin and NE reuptake

51
Q

SNRI also indicated for peripheral neuropathy?

A

Duloxetine

52
Q

SNRI that has greater effect on NE?

A

Duloxetine

53
Q

Most common side effect of SNRI (duloxetine and venlafaxine)

A

Increased blood pressure

54
Q

All TCAs end in blank or blank?

A

iptyline or ipramine except doxepin and amoxapine (yes, I know this is bullshit, but remember it anyhow)

55
Q

MOA of TCA?

A

block reuptake of NE and seretonin

56
Q

Antidepressant indicated for fibromyalgia?

A

TCA (end in “iptyline” or “ipramine” except doxepin and amoxapine)

57
Q

Pt. presents with postural hypotension after starting an antidpressent?

A

TCA have alpha 1 blocking effects which can cause postural hypotension

58
Q

Pt. presents with urinary retention, dry mouth and fast heart rate after starting an antidepressant?

A

TCA– have atropine like effects

59
Q

Amitriptyline has greater blank side effects than nortriptyline?

A

anticholinergic

60
Q

TCA with highest seizure threshold?

A

Desipramine

61
Q

Pt. presents with convulsions and arrhythmias after starting an antidepressant? How do we treat?

A

TCA– NaHCO3

62
Q

TCA that should be used in elderly?

A

Nortriptyline due to lesser anticholinergic side effects

63
Q

NaHCO3

A

Treatment for cardiovascular toxicity of TCA

64
Q

MAO inhibitors?

A

(MAO Takes Pride In Shanghai) Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline (MaO-B inhibitor)

65
Q

Pt. is taking an antidepressant. He begins to go into cardiac arrest after a wine and cheese party?

A

MAO inhibitors (Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline– hypertensive crisis with ingestion of tyramine

66
Q

Antidepressant that should not be taken with St. Johns Wart, Meperidine, and Dextromethorphan?

A

MAO inhibitors

Dextromethorphan and MAO can lead to seretonin syndrome

67
Q

Used for smoking cessation?

A

Bupropion– increased NE and dopamine via unknown mechanism

68
Q

Atypical antidepressent that may cause insomnia and seizure in bulimic patients but has no sexual side effects?

A

Bupropion

69
Q

Atypical antidepressant with alpha 2 antagonist activity and seretonin antagonist?

A

Mirtazapine– increased appetite and weight gain which may be desirable in elderly or anorexic patients

70
Q

atypical antidepressant that is used in elderly population due to weight gain and increase appetite?

A

mirtazapine

71
Q

Maprotiline?

A

Blocks NE reuptake– causes orthostatic hypotension

72
Q

Atypical antidepressant that causes orthostatic hypotention?

A

Maprotiline– blocks NE reuptake

73
Q

Used primarily for insomnia?

A

Trazadone– causes priapism and postural hypotension

74
Q

Buprenorphine

A

Used for Opioid withdrawal (eg heroin)

Elliot Step 1 (32 decks)

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