Neuro Flashcards
Contralateral hemiparesis; unmanaged HTN?
Lateral striate artery stroke
Lesion is in striatum (caudate+ putamen=striatum) or internal capsule
Pt presents with vomiting, vertigo, nystagmus, dec pain and temp sensation to limbs and face; can’t swallow and having trouble speaking– WHERE IS LESION? WHAT ARTERY? WHAT IS THIS CALLED?
1) Lesion is in lateral medulla (vestibular nuclei, later STT, spinal trigeminal nucleus, NUCLEUS AMBIGUUS, inferior cerebellar peduncle
2) PICA
3) Lateral medullary syndrome– nucleus ambiguus are specific to pica lesions
Pt. presents with contralateral heminaopia with macular sparing– Artery? Lesion?
1) PCA
2) Occipital cortex, visual cortex
Pt. presents with vomiting, nystagmus and vertigo. Pt.’s cannot lift up cheeks to smile. Pt. has decreased lacrimation, and dec corneal reflex– artery? Lesion? Name of disease?
1) AICA
2) Lateral pons– facial nucleus are specific to AICA (Facial droop means AICAs pooped
3) Lateral Pontine syndrome
Pt. presents with hemiparesis of right leg. Tongue deviates to left. Proprioceptive problems with right leg as well?
1) ASA– think about where artery is
2) Lateral corticospinal tract, medial lemniscus; caudal medulla is where hypoglossal nerve is
3) Medial medullary syndrome caused by paramedian branches of ASA and vertebral arteries
Anterior communicating aneurysms present with?
Visual defects
Posterior communicating strokes or aneurysms present with?
CN3 palsy– eye is down and out with ptosis and pupil dilation
MCC artery of berry aneurysm?
Anterior communicating
Epidural hematoma can lead to what kind of herniation?
Transtentorial– CN3 palsy
crescent shaped hemorrhage that crosses suture liens?
Subdural– bridging veins (atrophy predisposes to this)
Acute subdural on imaging?
Chronic subdural on imaging?
Acute=hyperdense
Chronic=isodense/hypodense
Spinal tap of SAH?
Bloody or yellow
2-3 days after SAH, there is a risk of ? What should this be treated with?
Risk of vasospasm and treat with CCB (nimodipine)
Intraprenchymal hemorrhage often seen with ?
Amyoid angiopathy, vasculitis, and neoplasm
Describe progression of ischemic brain disease? 2 weeks?
Red neurons appear from 12-48 hours
Necrosis plus neutrophils appear from 1-3 days after
Macrophages appear from 3-5 days after
Reactive gliosis and vascular proliferation occurs from 1-2 weeks after
Glial scarring happens>2 weeks after
Glial scar presents how long after brain injury?
> 2 weeks
Bright areas on noncontrast CT indicate?
hemorrhage–DO NOT GIVE TPA
Where does reabsorbed CSF drain into?
dural venous sinus
Communicating hydrocephalus?
Dec CSF absorption by arachnoid granulations–>papilledema, and herniation
Normal pressure hydrocephalus?
Increase in subarachnoid space volume but no increase in pressure–? Wet, wobbly, whacky
Hydrocephalus ex vauo?
Appearance of increased CSF due to atrophy (alzheimers, picks, HIV)
CN6 palsy, nausea, vomiting, papilledema?
Possibly noncommunicating hydrocephalus
Subarachnoid space extends to lower border of?
S2
Destruction of anterior horns; flaccid paralysis?
Polio– primarily effects legs
Random asymmetric lesions dt demyelination, scanning speech, intention tremor, nystagmus?
Multiple Sclerosis
UMN and LMN deficits with no sensory loss?
ALS (deficits in ventral horns and CST)
“Treatment” for ALS and defect?
Defect may be in superoxide dismutase
RiLOUzole– dec presynaptic glutamate release
Artery of adamkiewicz supplies ASA below?
T8
Tabes dorsalis effects?
Dorsal columns– assoc with charcot joints, shooting pain, argyll pupuils, also postivie Rombergs
Bilateral loss of pain and temp from c8-t1? assoc?
Syringomyelia– seen with chiari malformations
Impaired position and vibration sense and ataxia?
B12– affects dorsal columns and Cortical spinal tract
Where does polio virus replicate?
oropharynx and small intestine– fecal oral–>LMN
Werdnig hoffman?
Same as polio but there is CONGENITAL degeneration
Pes cavus, nystagmus, falls easily, dysarthria?
Friedrichs –die of cardiomyopathy
Brown sequard– losses AT the level of the lesion?
All sensory loss and ipsilateral LMN signs AT the level of the lesion
L1
inguinal ligament
umbilicus?
t10
Bicepts reflex?
c5
triceps reflex
c7
achilles reflex
s1
hang on for life reflex of baby?
moro
Movement of head to one side if cheek or mouth is stroked?
rooting
curling of fingers if palm is stroked?
Palmar
stroking along one side of spine while newborn is in ventral suspension causes lateral flexion of lower body toward stimulated side?
Galant reflex
Paralysis of conjugate vertical gaze due to lesion of superior colliculi?
Parinaud syndrome– dorsal midbrain is compressed; large irregular pupils, ptosis; impairment of upward gaze
sensation from anterior 2/3 of tongue
trigeminal
taste from anterior 2/3 of tongue– eye CLOSING
facial
Stapedius muscle is innervated by? passes through?
Stapedius is innervated by the facial nerve and passes through the parotid gland
Midline uvula?
Vagus
Talking CN?
Vagus– coughing, swallowing, palate elevation
Lateral nuclei (sensory) are derived from ?
aLar plate
Medial nuclei (motor) are derived from?
Basal plate
Nucleus solitarius?
Visceral sensory information (taste, barorectpros, gut distention)– 7, 9, 10
Nucleus ambiguus?
Swallowing, palate elevation 9, 10
Dorsal motor nucleus?
Sends parasympathetic fibers to heart, lungs, and upper GI— CN10
CN1 passes through?
Cribriform plate– ethmoid
cranial nerves 2-6 pass through?
sphenoid
Middle meningeal artery passes through?
foramen spinosum
CN7-12 pass throuhg?
Posterior cranial fossa
CN 7, 8?
pass through internal auditory meatus
CN 9,10,11 pass throuhg?
Jugular foramen
CN12 passes through?
hypoglossal canal
Brain stem, vertebral arteries, and spinal roots of CN 11 pass through?
Foramen magnus
Which cranial nerves pass through the cavernous sinus?
3,4,51,52,6
Opthalmoplegia, decreased corneal and maxillary sensation with normal vision
cavernous sinus syndrome
this muscle prevents jaw from deviating to opposite side?
Pterygoid
CN11 lesion?
Weakness moving head to contralateral side
Alleviates pressure created by oval window?
Round window
DDx for facial nerve palsy?
AIDS, lyme idsease, herpes, sarcoid, tumors, diabetes
Muscles of mastication? muscle that opens jaw
Temporalis, masster, medial pterygoid all close the jaw
lateral pterygoid opens jaw
Hyperopia?
Farsighted– light focuses behind retina
Myopia?
Near sighted– light focuses in front of retina
During accomodation lens becomes more….? Defect in accomodation is called?
Lens becomes more convex
Defect is called Presbyopia
Retinitis DDx?
CMV, HSV, HZV– associated with immunosuppresion
Retina whitening with cherry red spot?
Central retinal artery occlusion
Closed angle glaucoma?
Enlargement of lens pushing it against the central iris leading to obstruction of normal AH flow
Patient presents with sudden onset of excruciating pain in her eye. She has been corticosteroids for along time. She also has a frontal headache. What should NOT be given to this patient?
Epinephrine– dt mydriatic efffect
3 metabolic disorders that cause cataracts?
Classic galactosemia; galactokinase deficiency, diabetes (sorbitol)
26yo obese woman with H/N/V, visual changes?
Pseudotumor cerebri
Eye moves upward, problems going down stairs, contralateral gaze with ipsilateral head tilt?
Trochlear 4 damage
pathway of miosis?
Edinger westphal nucleus to ciliary ganglion via cnIII–>short ciliary nerves to pupillary sphincter muscles
Pathway of mydriasis?
hypothalamus to ciliospinal center of budge (c8-t2)–>exit at T1 to superior cervical ganglion– travels along sympathetic chain–>plexus along internal carotid– enters orbit at long ciliary nerve to pupillary dilator muscle
Central portion of oculomotor nerve?
motor output to ocular muscles
Peripheral portion of oculomotor nerve?
parasympathetic output– affected by compression
pathophys of dry macular degeneration?
Deposition of yellowish extracellular material beneath retinal pigment epithelium– PREVENT WITH MULTIVITAMIN AND ANTIOXIDANT
Pathophys of wet macular degeneration?
Rapid loss of vision due to bleeding secondary to choroidal neovascularization –TREAT WITH ANTI VEGF or laser
Bilateral MLF?
Multiple sclerosis
Telencephalon
Lateral Ventricles— Think of the top part of the T as the ventricles
Diencephalon?
Thalamus and third ventricle
mesen; meten; myelen
midbrain (aqueduct); pons/cerebellum (upper part of fourth ventricle); medulla (lower part of fourth ventricle
Helpful confirmatory test for neural tube defect in addition to high alpha fetoprotein
AChE
Dandy walker
agenesis of cerebeller vermis with cystic enlargement of fourth ventricle (fills the enlarged posterior fossa)– associated with hydrocephalus and spina bifida
Dopamine synthesized in?
Ventral tegmentum
ant. pituitary derived from?
Post pituitary derived from?
Ant= ectoderm Post= neuroectoderm
Lesion of arcuate fasciculus?
Cannot repeat sentences
Conduction deficit
Conduction can’t repeat– can be caused by damage to arcuate fasciculus
Transcortical lesions
CAN repeat
Hypoxemia increases cerebral perfusion only when PO2 is below 50mmHg or 70%
Freebie
Aphasia, ataxia, hemparesis, AIDS patient– path?
Progressive multifocal leukonencephalopathy
see eosinophilic inclusion– represents accumulation of JC virus
Looks like MS on MRI
Acute disseminated encephalomyelitis– measles of VZV