Endocrine Drugs

Question 1

Rapid acting insulin

Answer 1

Lispro; Aspart; glulisine

Question 2

Glargine and detemir?

Answer 2

Long acting insulin

Question 3

Effect of insulin on muscle?

Answer 3

INcreased glyogen and protein synthesis

Question 4

MOA of metforin?

Answer 4

activates AMPK– affects insulin sensitivity, not insulin release

Question 5

Diabetes drug that causes lactic acidosis?

Answer 5

Metformin (contraindicated in renal failure)

Question 6

MOA of sulfonureas?

Answer 6

Close K+ channel–>cell depolarization–>influx of Ca2+–>insulin release

Question 7

Diabetes class that can cause disulfiram like effects?

Answer 7

Sulfonylureas

Question 8

Tolbutamide?

Answer 8

Sulfonylurea

Question 9

Chlorpropamide?

Answer 9

Sulfonylurea

Question 10

Glyburide?

Answer 10

Sulfonylurea

Question 11

Glipizide?

Answer 11

Sulfonylurea

Question 12

Glitzaones: MOA? Toxcities?

Answer 12

Increase insulin sensitivity in peripheral tissue by binding PPAR gamma; hepatotoxicity, heart failure

Question 13

Patient starts drug and goes into heart failure?

Answer 13

Glitazones (also causes hepatotoxicity)

Question 14

Alpha glucosidase inhibitors?

Answer 14

Acarbose and miglitol

Question 15

MOA of acarbose?

Answer 15

Inhibits intestinal brush border alpha glucosidases; delays sugar hydrolysis and glucose absorption leading to decrease in postprandial hyperglycemia

Question 16

MOA of Miglitol?

Answer 16

Inhibits intestinal brush border alpha glucosidase

Question 17

Inhibits intestinal brush border alpha glucosidase?

Answer 17

Miglitol and Acarbose

Question 18

Slow gastric emptyings?

Answer 18

Pramlintide

Question 19

Pramlintide?

Answer 19

Amylin drug– slows gastric emptying

Question 20

Diabetes drug that causes pancreatitis?

Answer 20

GLP-1 analogs– Exenatide and Liraglutide

Question 21

MOA of GLP-1 analogs?

Answer 21

Slow gastric motility and increase satiety– incretins

Question 22

DPP-4 inhibitors?

Answer 22

Linagliptin; Saxagliptin; Sitagliptin

Question 23

MOA of gliptins?

Answer 23

DPP4 inhibitors– DPP4 inactivates GLP- 1, when dpp4 is uninhibited

Question 24

Diabetes drug that may lead to urinary or respiratory infection?

Answer 24

Linagliptin; Saxagliptin; Sitagliptin

Question 25

Increasing PPAR gamma leads to?

Answer 25

Increased insulin sensitivity and levels of adiponectin

Question 26

Block peroxidase?

Answer 26

PPU and Methimazole— inhibit organification of iodidi and coupling of thyroid hormone synthesis

PPU also blocks 5’ deiodinase

Question 27

PPU MOA? Toxicity?

Answer 27

Blocks peroxidase thereby inhibiting organification and coupling of thyroid hormone–ALSO blocks 5’ deiodinase (Hepatotoxic)

Question 28

Hyperthyroid drug that is hepatotoxic?

Answer 28

PTU

Question 29

Hyperthyroid drug that is teratogenic?

Answer 29

Methimazole

Question 30

Severe side effects of PTU and methimazole?

Answer 30

Agranulocytosis and aplastic anemia

Question 31

thyroid drug that causes tremors arrhythmias?

Answer 31

Levothyroxine or triiodothyronine

Question 32

Turner syndrome drug?

Answer 32

Growth hormone

Question 33

Controls uterine hemorrhage

Answer 33

Oxytocin

Question 34

ADH antagonist?

Answer 34

Demclocycline

Question 35

Demclocycline?

Answer 35

ADH antagonist

Question 36

May cause nephrogenic DI?

Answer 36

Demclocycline

Question 37

Toxicities of demclocycline?

Answer 37

Obviously DI; photosensitivity abnormalities in bone and teeth

Question 38

Cause bone and teeth abnormalities?

Answer 38

Demclocycline

Question 39

Corticosteroids inhibit?

Answer 39

Phospholipase A2 and expression of cox-2

Question 40

When this drug is stopped abruptly after chronic use is can cause adrenal insufficiency?

Answer 40

Glucocorticoids

Question 41

Used during a thyrotoxic crisis?

Answer 41

Iodide– has metallic taste