Renal Phys ML: 9 Flashcards
What is the intracellular concentration of K+
150mM
How is the intracellular concentration of K+ controlled?
through the Na/K ATPase pump
What is the extracellular K+ concentration?
5mM
How is the extracellular concentration of K+ controlled
by the kidneys
What can small changed in K+ concentration cause?
lethal malfunction of excitable tissues
What is hypokalmia
low K
What is hyperkalemia
high K+
Why is the resting mV lower with hypokalemia
lower ECF K+ concentration so it makes the gradient bigger and when K+ moves out more negative ions on membrane which makes the membrane more negative
Why is the resting mV higher with hyperkalemia
higher ecf K+ concentration so it makes the gradient smaller and so when K+ moves out of the cell there is less negative ions on membrane so it becomes more positive (depolled cell at rest)
What renal processes does K+ experience?
All 3:
- filtration
-reabsorption
-secretion
How is K+ reabsorbed
by the paracellular route
- K+ follows water which follows Na+
Where is K+ 65% reabsorbed and non regulated
in the proximal tubule
Where is K+ reabsorbed
proximal tubule and ascending limb
What regulates K+ secretion
aldosterone because it builds pumps and channels
What is the major function of the glomerulus/bowman’s capsule?
forms ultrafiltrate of plasma
