Renal Phys ML: 2 Flashcards
What percent of blood will flow through the afferent arteriole?
100%`
What percent of blood flows into the nephron?
20%
What percent of blood flows into the EA?
80%
Tubular reabsorption
the good substances that the body doesnt want to lose will be reabsorbed back into the capillary
Tubular Secretions
secreting undesirable substances into the nephron
Why does secretion not equal excretion
a change that substances can be reabsorbed back in
Drug and Toxin secretions
-freely filtered
-100% secreted
-undesirable substance
Na, Cl, Water secretions
-freely filtered
-partially reabsrobed
Glucose, Amino Acids
-freely filtered
-100% reabsorbed
Where does glomerular filtration take place?
renal corpuscle
Visceral layer of bowman’s capsule
podocute cells that are wrapped around the capillaries
How does the filtered blood leave bowmans capsule
proximal tubule
What do filtration slits allow
fluid to pass into bowman’s capsule
What are the three layers composing the filtration barrier
- capillary endothelium (fenestrated=more exchnage)
- Basement membrane (negatively charged matrix) shrink wrapped around capillary
- Bowman’s epithelium (podocutes and filtration slits)
What is filtrate
blood plasma except for RBCs and proteins
Why are there no RBC and proteins within the filtrate
-plasma proteins and cells too big for filtration
-negatively charged membrane exlcudes plasma proteins
What is a normal GFR
125 mL/min
Pgc
glomerular capillary pressure (60)
What decreases GFR
-constrict AA
-dilate EA
What increases GFR
-Constrict EA
-dilate AA
What are the forces that favor filtration
Pgc= the pressure in the glomerlar capillaries will push filtrate into bowman’s space
What forces oppose filtration?
Pbs= pressure of filtrate in bowmans space (15)
Pigs= osmotic force due to protein plasma (29)
-determined by plasma proteins
Pgs___ to opposing forces then filtration into bowmans space can occur
> , this is normal
FL>EL
net reabsorption
FL<El
Net secretion
