Renal Function Flashcards
4 main functions
Excretion
Regulation
Endocrine
Metabolic
Excretion
Waste + foreign substances
E.g. - urea, bilirubin, creatinine, uric acid, drugs
Regulation
Blood osmolarity Blood glucose level Blood pH Blood ionic composition Blood volume
Endocrine/metabolic
RBC synthesis
Production of hormones
Renin synthesis
Calcitrol
Renal failure consequences
Hypertension Anaemia Acidosis Build up of waste products Fluid overload/salt + water retention Renal osteodystrophy
GFR
Glomeruli filter ~100mL plasma/min
Normal >90ml/min/1.73
Creatinine
Serum creatinine increases when 50% kidney function lost
Subject to non-renal influences
eGFR
Combine serum creatinine level + other pt info
Look at trend
Values differ between labs
Creatinine level must be stable
Not suitable children or amputees
Caution if extreme muscle mass (high or low)
Blood urea
HIGH
Dehydration
Fever
Infection
Drugs
blood urea
LOW
Low protein diet
Liver failure
Dialysis
Blood urea
Low urea + creatinine
Over-hydration
Other tests
Full blood count Blood glucose Blood pressure Urine volume Radiology Ultrasound Renal biopsy Renal imaging Observation peripheral oedema Plasma Na, K, Ph, bicarbonate
