Crohn's Disease Flashcards

1
Q

Clinical features

A
Diarrhoea
Abdo pain
Anorexia
Fever
Intestinal obstruction
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2
Q

Complications

A
Fistulae
Obstruction
Strictures
Ulcers
Haemorrhage
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3
Q

40% occur

A

In ileocecal region

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4
Q

Surgical management

A

Take out diseased part but disease is not gone

Less GI tract for nutrient absorption

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5
Q

Surgical management:

Strictureplasty

A

Opens up narrowings of the bowel

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6
Q

Surgical management:

Resection

A

Part of small bowel removed

Proctocolectomy

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7
Q

Dietary management:

Child energy req

A

500-1400kcal higher than normal

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8
Q

Dietary management:

In those with strictures + obstructive symptoms

A

Diet with adapted texture or distal enteral nutrition

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9
Q

Benefits of nutrition support

A

Bowel rest
Social effects
Immunological effects
Intestinal adaptation

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10
Q

Exclusive enteral nutrition

A

Associated with 60-80% remission rate

Can decrease local + systemic inflammation

Promote weight gain

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11
Q

Exclusive enteral nutrition:

Modulen IBD

A
Nestle
Contains TGF-B2
Whole protein powder
Can be conc to 1.5kcal/ml
Oral or tube feeding
Can be flavoured
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12
Q

Exclusive enteral nutrition:

Supplementary

A

Overnight feeding
Oral supplements
Significant short-term benefits

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13
Q

Exclusive enteral nutrition:

Common feed related problems

A
Hunger
Nausea
Unable to manage feed volumes
Diarrhoea
School/social disruption
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14
Q

Exclusive enteral nutrition:

Forbes ESPEN guidelines

A

First line to induce remission in children + adolescents with active CD

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15
Q

Enteral nutrition as primary therapy

Cochrane review

A

Less effective than conventional corticosteroid therapy

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16
Q

Enteral nutrition as primary therapy:

Benefits

A

Improves nutritional status

Fewer side effects

17
Q

Elemental vs polymeric

A

Cochrane systematic review - no significant difference in efficacy

Elemental limitations - taste, quantity, nausea, osmotic diarrhoea

18
Q

Exclusion diets

A

Not recommended to achieve remission in active CD

19
Q

Food reintroduction:

LOFFLEX

A

Low fat, fibre limited exclusion diet
Based on foods less likely to cause intolerance
Fat ~50g/d and fibre ~10NSP/d

A: speeds up reintroduction process (takes ~2-4wk)

Allowed - lean meat, soya milk, sunflower/olive oil, sugar/honey/jam

20
Q

Pre-, pro- and synbiotics

A

No strong evidence of effectiveness of pre or pro biotics

Synbiotics show some potential but confirmatory evidence required