[RECALLS] Topic 29: Hemostasis By: Dr. Johanna Dimacisil Flashcards
Activated on surface of activated platelets by tenase complex and by factor VII, Ca, and tissue factor
a. Factor VIII
b. Factor X
c. Factor IX
b. Factor X
Activated on surface of activated platelets by prothrombinase complex
a. Factor II
b. Thrombin
c. Factor III
a. Factor II
A glycoprotein expressed on the surface of injured or stimulated endothelial cells to act as a cofactor for factor VIIa
a. Factor VIII
b. Tissue Factor (Factor III)
c. Factor VII
b. Tissue Factor (Factor III)
Platelets must first be activated to expose the phospholipids phosphatidylserine and phosphatidylinositol
a. Extrinsic pathway
b. Tenase Complex
c. Intrinsic pathway
b. Tenase Complex
Forms a complex with factor Xa and prothrombin
a. Factor V
b. Factor III
c. Factor VIII
a. Factor V
Amino terminal has 10 la residues; carboxyl terminal serine – dependent active protease site in prothrombinase complex
a. Thrombin
b. Proaccelerin
c. Prothrombin
c. Prothrombin
Prothrombin is cleaved by factor Xa at 2 sites to generate 2 chain thrombin molecule held by
a. Hydrogen bond
b. Disulfide bond
b. Disulfide bond
Thrombin releases this peptide to generate fibrin monomer
a. Fibrinopeptides
b. Thrombopeptides
a. Fibrinopeptides
Factor XIII covalently cross links fibrin monomers by
a. Forming peptide bonds between amide group of glutamine and amino group of lysine
b. Forming peptide bonds between amide group of lysine and amino group of glutamine
a. Forming peptide bonds between amide group of glutamine and amino group of lysine
Plasmin circulates in its inactive form plasminoen is mainly responsiblefor degrading fibrin and fibrinogen
a. Plasmalysis
b. Thrombolysis
c. Fibrinolysis
c. Fibrinolysis
Fast acting plasmin inhibitor that rapidly inactivates any small amount of plasmin
a. Beta2 antiplasmin
b. Alpha2 antiplasmin
b. Alpha2 antiplasmin
Is synthesized by monocytes, macrophage, fibroblast, epithelial cells
a. Urokinase
b. Prourokinase
b. Prourokinase
Used therapeutically as fibrinolytic agents
a. Recombinant t-PA
b. Streptokinase
c. both
c. both
Irreversibly acetylates and inhibits cyclooxygenase system, involve in the formation of thromboxane A2
a. Aspirin
b. Vitamin K
a. Aspirin
A polypeptide synthesizes in the endothelial cells and megakaryocytes
a. vwF
b. Factor VIII
a. vwF
